혈액질환 환자에서 발생한 대장암 (Colon Cancer Secondary to Hematologic Disease)

서지정보

· 발행기관 : 대한대장항문학회
· 수록지 정보 : Annals of Coloproctolgy / 25권 / 4호 / 248 ~ 251페이지
· 저자명 : 김도형, 지성배, 시윤, 이윤석, 강원경, 오승택, 이인규

초록

Purpose: The incidence of secondary malignancies in hematologic patients is known to be higher than it is in other patients.
However, the characteristics of secondary malignancy and surveillance have not yet been established for colorectal cancer
in leukemic patients.
Methods: From 1995 to 2007, 6,030 patients who were diagnosed with acute myeloid leukemia (AML), acute lymphoid
leukemia (ALL), chronic myeloid leukemia (CML), chronic lymphoid leukemia (CLL), and multiple myeloma (MM) were enrolled
in this study. Among them, 9 patients were diagnosed with colorectal cancer at St. Mary’s Hospital and were analyzed retrospectively.
Results: Three of the 2,570 patients with AML, 1 of the 1,158 patients with CML, 2 of the 83 patients with CLL, 2 of the 422
patients with MM, and none of the 1,797 patients with ALL were found to have colorectal cancer. There were no operative
mortalities, but 2 patients refused to have surgery. The ratio of observed to expected subsequent colorectal cancer in CLL
was higher than it was in the other groups, indicating that the relative risk of colorectal cancer is higher in patients with CLL.
Conclusion: Compared to the Surveillance, Epidemiology and End-Result (SEER) program at the National Cancer Institute
(NCI) in the United State, we have the same high relatively risk in CLL patients. Careful attention should be paid to the possibility
of colorectal cancer in CLL patients.

영어초록

Purpose: The incidence of secondary malignancies in hematologic patients is known to be higher than it is in other patients.
However, the characteristics of secondary malignancy and surveillance have not yet been established for colorectal cancer
in leukemic patients.
Methods: From 1995 to 2007, 6,030 patients who were diagnosed with acute myeloid leukemia (AML), acute lymphoid
leukemia (ALL), chronic myeloid leukemia (CML), chronic lymphoid leukemia (CLL), and multiple myeloma (MM) were enrolled
in this study. Among them, 9 patients were diagnosed with colorectal cancer at St. Mary’s Hospital and were analyzed retrospectively.
Results: Three of the 2,570 patients with AML, 1 of the 1,158 patients with CML, 2 of the 83 patients with CLL, 2 of the 422
patients with MM, and none of the 1,797 patients with ALL were found to have colorectal cancer. There were no operative
mortalities, but 2 patients refused to have surgery. The ratio of observed to expected subsequent colorectal cancer in CLL
was higher than it was in the other groups, indicating that the relative risk of colorectal cancer is higher in patients with CLL.
Conclusion: Compared to the Surveillance, Epidemiology and End-Result (SEER) program at the National Cancer Institute
(NCI) in the United State, we have the same high relatively risk in CLL patients. Careful attention should be paid to the possibility
of colorectal cancer in CLL patients.

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