In this experiment, we were able to synthesize Grignard reagents through Grignard reaction of magnesium and bromobenzene. Also, triphenylcarbinol is synthesized through a reaction of benzophenone and HCl with the Grignard reagent synthesized previously. We were able to determine whether the product is triphenylcarbinol or not by comparing the m.p. of the product and triphenylcarbinol.
Objectives: The Grignard agent is synthesized under anhydrous and anaerobic conditions, and triphenylcarbinol is synthesized through the reaction of the Grignard agent and ester.Principles & Methods:(1) Principles: Grignard reaction is a reaction between an alkyl(aryl) halide and magnesium in ether, which produces an alkylmanganesium (or arylmagnesium) halide.
In this experiment, we were able to synthesize the photochromic dye for two steps: the Knoevenagel condensation of 1,3-dimethylbarbituric acid with 2-furaldehyde and DASA formation. After the first step, the Knoevenagel product, which is called 5-(2-Furanylmethylene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione, is formed and it was in the form of a solid with a yellow color. After DASA formation in which this and diethylamine are dissolved in THF to react
Objectives: The synthesis of Donor-Acceptor Stenhouse Adduct (a.k.a. DASA) and the color comparison with the final product after irradiation of light can be used to observe its photochemical cyclization reaction and to understand negative photochromism.Principles & Methods:(1) Principles: Photochromism is the reversible transformation of a chemical species between two forms by the absorption of electromagnetic radiation.
Objectives: The Grignard agent is synthesized underUnknown biaryl products are synthesized by the Suzuki-Miyaura cross-coupling reaction of unknown aryl boronic acid and unknown aryl bromide. Also, the substituted biaryl product is presumed by comparing the m.p. with the anticipated products.Principles & Methods:(1) Principles: Suzuki-Miyaura cross-coupling (SMC) reaction is a palladium-catalyzed carbon-carbon bond forming reaction.