DNA Methylation

소개

DNA Methylation에 관한 레포트입니다.

목차

서 론
DNA Methylation이란?

본 론
1. DNA Methylation
2. 메틸화작용(Methylation)
3. Normal DNA Methylation
4. Functions of Methylation
5. Histone Methylation
6. 유전자 조절에서의 Methylation
7. 유전자 조절 비밀 간직한 Methylation
8. RNA의 Methylation을 위한 장소
9. CpG Methylation
10. 대장균의 dam과 dcm Methylation
11. 결장암의 발병을 촉진하는 DNA 메틸화
12. DNA Methylation에 관한 뉴스기사

결 론
참고문헌

본문내용

DNA Methylation이란?

DNA 메틸화(DNA Methylation)는 유전자 발현의 조절기작 중의 하나로 DNA 염기서열을 Methyl기로 치환시켜서 DNA의 반응성을 낮추고 안정성을 높여서 유전자 발현을 억제하는 기작 중 하나이다.
DNA는 처음 복제되었을 때에는 Methylation이 되어있지 않지만 복제 후에는 Methylation이 된다. 이와 비슷한 기작으로 히스톤(histon) 단백질에서 아세틸화(acetylation)가 일어나기도 한다.

1. DNA Methylation
DNA Methyltransferase - an enzyme that maintains the original pattern of DNA methylation by preferentially methylating the cytosine residues at hemimnethylated CpG sites [ 번역 : DNAMethyltransferase- 우선으로 시토신 잔류물을 메틸을 섞어서DNA메틸화의 원래 본을 유지하는 효소는CpG위치를 hemimnethylated ]

참고자료

· 1. Egger G, Liang G, Aparicio A, Jones PA. 2004. Epigenetics in human disease and prospects for epigenetic therapy. Nature, 428:457-463
· 2. Ehrlich M, Gama-sosa MA, Huang LH. 1982. Amount and distribution of 5-methylcytosine in human DNA from different types of cess. Nucleic Acid Res. 10:2709-2721.
· 3. Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142
· 4. Department for Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan
· 5. Sequenom, Inc., 3595 Johns Hopkins Court, San Diego, CA 92121
· 6. Novartis Institutes for Biomedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139
· 7. Jones PA, Taylor SM. 1980. Cellular differentiation, cytodine analogs, and DNA methylation. Cell: 20: 85-93
· 8. Bartolomei MA, Tilghman SM. 1997. Genomic omprinting in mammals. Ammu. Rev. Genet. 31:493-525
· 9. Tucker MS, Bestor TH. 1997. Formation of methylation petterns in mammalian genome. Mutation Res. 386: 119-130
· 10. Kass Su, Pruss D, Wolffe Ap. 1997. How does DNA methylation repress transcription? Trends Genet. 13:444-449
· 11. Tate PH, Bird Ap. 1993. Effects of DNA methylation on DNA-binding preteins and hene expression. Curr Opin. Henet. Dev. 3:226-231