thyroid cancer

소개

갑상선암 총18쪽분량으로 자세하게 기술했습니다. 레퍼런스도 사비스톤과 병리학책과 해리슨 참고해서 본과생들에게 아주 적합합니다~ 물론 용어는 모두 영어입니다~ 돈이 안아까울만큼 기술돼 있을겁니다.

목차

1. General Characteristics
2. Anatomy
3. Thyroid Oncogenesis
(1) Oncogene Activators
(2) Tumor Suppressor Genes: p53
4. Papillary thyroid cancer
(1) Pathologic Classification
(2) Clinical Presentation
(3) Treatment
5. Follicular thyroid cancer (FTC)
(1) Pathologic Classification
(2) Clinical Presentation
(3) Treatment
6. Hrthle Cell Carcinoma
7. Medullary Carcinoma
(1) Clinical Presentation
(2) Treatment
8. Anaplastic Thyroid Cancer
(1) Pathology
(2) Treatment
9. Lymphoma
(1) Work-Up and Diagnosis
(2) Treatment
10. Surgical complication

본문내용

8. Anaplastic Thyroid Cancer

▶ less than 1% of all thyroid malignancies

▶ the most aggressive form of thyroid cancer.

▶ older patient who presents with dysphagia, cervical tenderness, and a painful neck mass.

▶ The clinical situation deteriorates rapidly into tracheal obstruction and rapid local invasion of surrounding structures.


(1) Pathology

A. Grossly, locally invasive, with a firm, whitish appearance.

B. Microscopically, giant cells with intranuclear cytoplasmic invaginations

C. A wide variety of cell types, ranging from moderately differentiated to extremely poorly differentiated cell types

(2) Treatment

Most reports with resection : not optimistic.
- If anaplastic carcinoma initially presents with a resectable mass, some small improvement in survival may be made.
- The finding of distant metastasis or invasion into locally unresectable structures, such as the trachea -> should lead to a more conservative surgical approach, such as tracheostomy.

참고자료

· ⑴ Sabiston 17th, Elsevier saunders
· ⑵ Clinical oncology, Elsevier Churchill Livingstone
· ⑶ Harrison 22nd, McGrawHill