PSGN, Ig A nephropathy

소개

PSGN, Ig A nephropathy에 대한 리포트입니다..
모두 영어로 되어 있으며, 소아과나 내과 신장학 공부 하시는 분들에게 도움 될 것으로 봅니다....

목차

<Acute Poststreptococcal Glomerulonephritis>
1. Etiology and Epidemiology.
2. Pathology.
3. Pathogenesis.
4. Frequency
5. Mortality/Morbidity
6. Race, sex, age
7. Clinical Manifestations.
8. Diagnosis.
-Lab Studies-
① Urine
② Streptococcal infection
③ Hemolytic complement
④Renal
⑤ Blood
9. Imaging Studies
10. Complications.
11. prevention
12. treatment
13. prognosis
<참고> Other Chronic Infections

IgA Nephropathy (Berger nephropathy)
<참고> Isolated Glomerular Diseases with Recurrent Gross Hematuria
1. Pathogenesis
2. Frequency
-United States-
3. Mortality/Morbidity
4. Race, sex, age
5. Pathology and Pathologic Diagnosis.
6. Clinical and Laboratory Manifestations.
7. Prognosis and Treatment
8. Treatment
1. Medical Care
2. Surgical Care
3. Diet

본문내용

Diagnosis.
-Lab Studies-
① Urine
-Urine output most often is reduced, and urine is concentrated and acidic.
-Glucosuria occurs occasionally, and proteinuria is commonly present.
-The urine reaction for protein rarely exceeds 3+ by dipstick, corresponding to fewer than 2 g/m2/d when assessed quantitatively.
-Approximately 2-5% of children with PSAGN have massive proteinuria and a nephrotic picture.
② Streptococcal infection
-Look for evidence of streptococcal infection in all patients.
-Cultures from either the pharynx or skin may be positive; however, high streptococcal antibody titers are more compelling.
-A number of laboratory tests can be used to measure antibodies to a variety of streptococcal antigens (eg, ASO, AH, anti-DNase B) or to combinations of antigens (eg, streptozyme test).
③ Hemolytic complement
-Total hemolytic complement and some of its components are low during PSAGN.
-The concentration of C3 has been found to be decreased in more than 90% of patients with PSAGN when measured serially during the first 2 weeks of the illness.
-Total hemolytic complement values are also depressed.
-These tests help to differentiate poststreptococcal from other postinfectious forms of AGN.

참고자료

· 홍창의 소아과학 8판 p930~934, 939~939
· Nelson Textbook of Pediatrics 17판 p1694~1696
· www.nature.com
· www.emedicine.com
· http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed