[의학약학]acute myeloid leukemia (AML)

소개

AML의 정의, 분류, 스크리닝, 진단, 치료 등 AML에 대해 전반적으로 정리해 놓은 파워 포인트 파일 입니다.

목차

Acute Myeloid leukemia
Definition
Etiology
 Heredity
 Radiation
Drugs
Incidence
 AML
 In Korea

Classification
FAB Classification
Symptoms & sign
 Symptoms
 Physical findings
 Pretreatment evaluation
Prognostic factor
Treatment
 Induction chemotherapy
 Supportive care
 Post-remission therapy

본문내용

Infiltration of blood, BM, and other tissues by neoplastic cells of the hematopoietic system

Heredity
Somatic cell chromosome abnormalities
Down, Klinefelter, Patau
Excessive chromatin fragility
Fanconi anemia, Bloom synd., ataxia telangiectasia, Kostmann synd.

Radiation
5-7 years after atomic bomb exposure
Therapeutic radiation : add little risk
Alkylating agents : increase risk

Chemical and other exposures
Benzene : AML, CML, AA
Smoking, petroleum products, paint, embalming fluid, ethylene oxide, herbicide, pesticide

Drugs
Alkylating agents (MDS, AML)
: 4-6 yrs after exposure, chromosome 5, 7
Chlorambucil, melphalan, nitrogen mustard
Epipodophyllotoxin (Topoisomerase II inhibitor)
Etoposide, Teniposide
Chromosome 11q23 after 1-3 years
Chloramphenicol, Phenylbutazone, Chloroquine, Methoxypsoralen

참고자료

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