[내분비내과] osteoporosis

소개

osteoporosis나름대로 잘 정리되어 있어요...

목차

1. Definition
2. Epidemiology
3.pathophysiology
4.진단
5.치료

본문내용

1. Definition: A reduction of bone mass(or density)
or the presence of a fragility fracture
* deterioration in the architecture of the skeleton이 동반됨 → fracture의 risk가 현저히 증가함
* bone density that falls 2.5 standard deviations(SD) below the mean(T-score of -2.5)

2. Epidemiology
① bone tissue가 점진적으로 손실됨으로 osteoporosis는 increasing age함에 따라 더 자 주 나타남
② In women, the loss of ovarian function at menopause precipitates rapid bone loss (typically after age 50)
③ The epidemiology of fractures follows similar trends as the loss of bone density
* Risk Factors for Osteoporosis Fracture
Nonmodifiable
Personal history of fracture as an adult
History of fracture in first-degree relative
Female sex
Advanced age
Caucasian race
Dementia
Potentially modifiable
Current cigarette smoking
Low body weight [< 58㎏]
Estrogen deficiency
Early menopause (<45 years) or bilateral ovariectomy
Prolonged premenstrual amenorrhea (>1 year)
Low calcium intake
Alcoholism
Impaired eyesight despite adequate correction
Recurrent falls
Inadequate physical activity
Poor health/frailty

참고자료

· 해리슨, 파워내과, 강의록 등등에서 발췌함