혈액응고기전 및 이해

목차

1. Hemostasis overview
2. Hemostasis in physiology
3. Primary hemostasis
4. Blood vessel and endothelial cell
5. Platelet adhesion and aggregation
6. Antiplatelet therapy targets
7. Secondary hemostasis
8. Intrinsic and extrinsic pathways of coagulation
9. Interaction of thrombin and fibrinogen
10. fibrinolysis
11. The action of Plasmin
12. Evaluation of bleeding disorder
13. Inherited bleeding disorder
14. Vt K deficiency
15. DIC (disseminated intravascular coagulopathy)
16. DIC = Consumptive coagulopathy
17. Causes of DIC – acute DIC
18. Causes of DIC – chronic DIC
19. Causes of DIC – localized
20. Pathophysiology
21. Main features of DIC
22. Laboratory findings
23. Diagnosis
24. Considerations at diagnosis
25. Treatment I
26. Treatment II
27. Transfusion in DIC
28. Differential diagnosis
29. MAHA (microangiopathic hemolytic anemia)
30. TTP (Thrombotic thrombocytopenic purpura)

본문내용

The components of normal hemostasis - Blood vessels - platelets - plasma coagulation factors - their inhibitors and fibrinolytic system.

Vasoconstriction - constricts the blood vessel - minimize vessel diameter and slow bleeding
Platelets bind to collagen in the exposed walls of the blood vessel
Form a hemostatic plug within seconds after an injury

<중 략>

Tx of underlying disorder
PLT & coagulation factor replacement
Not recommended in routine setting
Ongoing bleeding
Invasive procedures
PLT < 20,000/mm3
Vt K replacement

Antithrombin III
Most study: improve lab values and even organ function
Large-scale randomized trial: failed to demonstrate mortality benefit
Heparin
No beneficial effect has been established
Limmiting effect in AT def. state
Already high risk of hemorrhage
Used in obvious thromboembolic disease
Used in chronic DIC

참고자료

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