Ischemic myelopathy is a disorder of acute onset that is
characterized by nonprogressive, mono-, hemi-, or quadriparesis/
plegia unless ascending or descending myelomalacia
develops [4, 16]. Ischemic myelopathy has been
described in several species, including humans [7, 18, 20],
dogs [2, 5, 8, 9, 17], horses [22], pigs [23], sheep [10], turkeys
[21], and cats [1, 3, 6, 12–14, 19, 24, 25]. In humans,
ischemic myelopathy may be caused by atherosclerosis,
vasculitis, embolism, infection, surgery, or trauma [18]. In
animals, the proposed etiologies include fibrocartilaginous
embolism, thromboembolism, hypercoagulability, vasculopathy,
septic embolization, and parasitic embolization [4,
16]. The definitive diagnosis of ischemic myelopathy
requires histologic examination [4, 16]. The antemortem
suspicion of ischemic myelopathy is based on a complete
medical history in addition to clinical symptoms with an
acute onset of nonpainful, nonprogressive (after the first 24
hr), and often asymmetric clinical signs. The potential etiologies
of spinal lesions should be ruled out by performing
radiographies, ultrasound examinations, cerebrospinal fluid
(CSF) analyses, myelographies, computed tomographies,
and magnetic resonance imaging (MRI) [8, 18]. MRI is
helpful in supporting the antemortem diagnosis of ischemic
myelopathy because the procedure, in addition to excluding
the other etiologies of myelopathy, may reveal signal intensity
· 1. Abramson, C. J., Platt, S. R. and Stedman, N. L. 2002. Tetraparesis
· in a cat with fibrocartilaginous emboli. J. Am. Anim.
· Hosp. Assoc. 38: 153–156.
· 2. Abramson, C. J., Garosi, L., Platt, S. R., Dennis, R. and McConnell,
· J. F. 2005. Magnetic resonance imaging appearance of
· 244.
· 11. Knipe, M. F., Vernau, K. M., Hornof, W. J. and LeCouteur, R.
· A. 2001. Intervertebral disc extrusion in six cats. J. Feline.
· Med. Surg. 3: 161–168.
· 12. MacKey, A. D., Rusbridge, C., Sparkes, A. H. and Platt, S. R.
· 2005. MRI characteristics of suspected acute spinal cord infarction
· in two cats, and a review of the literature. J. Feline
· Med. Surg. 7: 101–107.
· 13. Mikszewski, J. S., Van Winkle, T. J. and Troxel, M. T. 2006.
· Fibrocartilaginous embolic myelopathy in five cats. J. Am.
· Anim. Hosp. Assoc. 42: 226–233.
· 14. Mitsuda, M., Yoshioka, H., Akagi, Y., Mashita, T. and Uchida,
· K. 2007. Suspected fibrocartilaginous embolism in a cat with
· spinal infarction. J. Anim. Clin. Med. 16: 115–118 (in Japanese
· with English summary).
· 15. Munana, K. R., Olby, N. J., Sharp, N. J. and Skeen, T. M.
· 2001. Intervertebral disc disease in 10 cats. J. Am. Anim. Hosp.
· Assoc. 37: 384–389.
· 16. Neer, T. M. 1992. Fibrocartilaginous emboli. Vet. Clin. North
· Am. Small Anim. Pract. 22: 1017–1026.
· 17. Risio, L. D., Adams, V., Dennis, R., McConnell, F. and Platt,
· S. 2007. Magnetic resonance imaging findings and clinical
· associations in 52 dogs with suspected ischemic myelopathy. J.
· Vet. Intern. Med. 21: 1290–1298.
· 18. Sandson, T. A. and Friedman, J. H. 1989. Spinal cord infarction:
· report of 8 cases and review of the literature. Medicine
· (Baltimore) 68: 282–292.
· 19. Scotte, H. W. and O’Leary, M. T. 1996. Fibrocartilaginous
· embolism in a cat. J. Small Anim. Pract. 37: 228–231.
· 20. Simonson, T. M. and Yuh, W. T. 1996. Stroke and cerebral
· ischemia. pp. 767–786. In: Clinical Magnetic Resonance Imaging,
· 2nd ed. (Edelman, R. R., Zlatkin, M. B. and Hesselink, J.
· R. eds.), Saunders, Philadelphia.
· 21. Stedman, N. L., Brown, T. P. and Rowland, G. N. 1998. Intravascular
· cartilaginous in a tayra (Eira Barbara): a case report. J.
· Zoo Wildl. Med. 29: 470–473.
· 22. Taylor, H. W., Vandevelde, M. and Firth, E. C. 1977. Ischemic
· myelopathy by fibrocartilaginous emboli in a horse. Vet.
· Pathol. 14: 479–481.
· 23. Tessaro, S. V., Doige, C. E. and Rhodes, C. S. 1983. Posterior
· paralysis due to fibrocartilaginous embolism in two weaner
· pigs. Can. J. Comp. Med. 47: 124–126.
· 24. Turner, P. V., Percy, D. H. and Allyson, K. 1995. Fibrocartilaginous
· embolic myelopathy in a cat. Can. Vet. J. 36: 712–
· 713.
· 25. Zaki, F. A., Prata, R. G. and Werner, L. L. 1976. Necrotizing
· myelopathy in a cat. J. Am. Vet. Med. Assoc. 169: 228–229.
· suspected ischemic myelopathy in dogs. Vet. Radiol. Ultrasound
· 46: 225–229.
· 3. Bischel, P., Vandevelde, M. and Lang, J. 1984. L’infarctusde la
· moelle epiniere a la suite d’embolies fibrocartilagineuses chez
· le chien et la chat. Schweiz. Arc. Tierheilkd. 126: 387–397 (in
· French).
· 4. Cauzinille, L. 2000. Fibrocartilaginous embolism in dogs. Vet.
· Clin. North Am. Small Anim. Pract. 30: 155–167.
· 5. Cauzinille, L. and Kornegay, J. N. 1996. Fibrocartilaginous
· embolism of the spinal cord in dogs: review of 36 histologically
· confirmed cases and retrospective study of 26 suspected
· cases. J. Vet. Intern. Med. 10: 241–245.
· 6. Coradini, M., Johnstone, I., Filippich, L. J. and Armit, S. 2005.
· Suspected fibrocartilaginous embolism in a cat. Aust. Vet. J.
· 83: 550–551.
· 7. Duprez, T. P., Danvoye, L., Hernalsteen, D., Cosnard, G., Sindic,
· C. J. and Godfraind, C. 2005. Fibrocartilaginous embolization
· to the spinal cord: serial MR imaging monitoring and
· pathologic study. AJNR Am. J. Neuroradiol. 26: 496–501.
· 8. Gandini, S., Cizinauskas, S., Lang, J., Fatzer, R. and Jaggy, A.
· 2003. Fibrocartilaginous embolism in 75 dogs: clinical findings
· and factors influencing the recovery rate. J. Small Anim.
· Pract. 44: 76–80.
· 9. Hawthorne, J. C., Wallace, L. J., Fenner, W. R. and Waters, D.
· J. 2001. Fibrocartilaginous embolic myelopathy in miniature
· schnauzers. J. Am. Anim. Hosp. Assoc. 37: 374–383.
· 10. Jeffery, M. and Wells, G. A. 1986. Multifocal ischemic
· encephalomyelopathy associated with fibrocartilaginous
· emboli in the lamb. Neuropathol. Appl. Neurobiol. 12: 231–