탈미네랄화된 골분용액을 함침시킨 PLGA 지지체의 제조 및 특성 (Fabrication and Characterization of PLGA Scaffold Penetrated with Demineralized Bone Solution)

서지정보

· 발행기관 : 한국조직공학과 재생의학회
· 수록지 정보 : 조직공학과 재생의학 / 5권 / 2호 / 229 ~ 234페이지
· 저자명 : 백미옥, 김순희, 소정원, 임지예, 최진희, 이종문, 이해방, 강길선

초록

We developed the synthetic/natural hybrid scaffolds with poly (lactide-co-glycolide)(PLGA) and solution
using DBP(DB solution) for tissue engineering. Composite scaffolds of PLGA scaffold penetrated DB solution(PLGA-pen-DBP) were manufactured by simple method that PLGA scaffolds manufactured by solvent casting/salt leaching method soaked in DB solution. We evaluated pore structure, wettability, water uptake ability and cell viability of two types of scaffolds. Through SEM and FT-IR, it was confirmed that DB solution was put into the pores of PLGA scaffold. Also, the effects of the impregnation of DB solution on PLGA scaffolds were characterized through water uptake ability and cell viability. It seemed that DBP provided proper pore to PLGA scaffold and improved water absorption. A novel scaffold, which PLGA scaffold penetrated with DB solution, might be suitable to apply as tissue engineered scaffold.

영어초록

We developed the synthetic/natural hybrid scaffolds with poly (lactide-co-glycolide)(PLGA) and solution
using DBP(DB solution) for tissue engineering. Composite scaffolds of PLGA scaffold penetrated DB solution(PLGA-pen-DBP) were manufactured by simple method that PLGA scaffolds manufactured by solvent casting/salt leaching method soaked in DB solution. We evaluated pore structure, wettability, water uptake ability and cell viability of two types of scaffolds. Through SEM and FT-IR, it was confirmed that DB solution was put into the pores of PLGA scaffold. Also, the effects of the impregnation of DB solution on PLGA scaffolds were characterized through water uptake ability and cell viability. It seemed that DBP provided proper pore to PLGA scaffold and improved water absorption. A novel scaffold, which PLGA scaffold penetrated with DB solution, might be suitable to apply as tissue engineered scaffold.

참고자료

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