주요우울장애 여성의 피질 두께와 회백질 용적의 특징 (Characteristics of Cortical Thickness and Brain Volume in Females with Major Depressive Disorder)

서지정보

· 발행기관 : 대한인간공학회
· 수록지 정보 : 대한인간공학회지 / 38권 / 5호 / 361 ~ 371페이지
· 저자명 : 석지우, 손진훈

초록

Objective: The purpose of this study is to find brain areas shown a difference of the volume and cortical thickness between females with major depressive disorder (MDD) and healthy females.
Background: Although neuroimaging studies on the characteristics of MDD have been accumulating, limited studies have used both brain volume and cortical thickness to find the structural alteration in MDD. Integrating measures of structural brain imaging provide profound insights into the neurobiological underpinnings of MDD.
Method: Twenty-two females with MDD and 23 age- and sex-matched healthy females participated in this study. A 3T Philips Achieva MRI scanner (Philips Medical Systems, Best, The Netherlands) was used for image acquisition. Gray matter volume and cortical thickness were analyzed using voxel-based morphometry (VBM) and surface-based morphometry (SBM).
Results: VBM results indicated that individuals with MDD had significantly reduced gray matter volume in the anterior cingulate gyrus, hippocampus, hippocampal gyrus and precuneus and cerebellum compared to controls. Moreover, gray matter volume in the right anterior cingulate gyrus was negatively correlated with the severity of depression. SBM results demonstrated that compared to healthy controls, individuals with MDD showed reduced cortical thickness in temporal pole, paracentral gyrus, angular gyrus and insula.
Conclusion: These findings suggest that structural alterations in the anterior cingulate gyrus are linked to MDD, thereby providing understanding into the neural mechanisms underlying MDD.
Application: Alterations in the anterior cingulate cortex may act as neuroimaging markers of MDD, and these findings provide a possibility to developed the diagnosis system for MDD.

영어초록

Objective: The purpose of this study is to find brain areas shown a difference of the volume and cortical thickness between females with major depressive disorder (MDD) and healthy females.
Background: Although neuroimaging studies on the characteristics of MDD have been accumulating, limited studies have used both brain volume and cortical thickness to find the structural alteration in MDD. Integrating measures of structural brain imaging provide profound insights into the neurobiological underpinnings of MDD.
Method: Twenty-two females with MDD and 23 age- and sex-matched healthy females participated in this study. A 3T Philips Achieva MRI scanner (Philips Medical Systems, Best, The Netherlands) was used for image acquisition. Gray matter volume and cortical thickness were analyzed using voxel-based morphometry (VBM) and surface-based morphometry (SBM).
Results: VBM results indicated that individuals with MDD had significantly reduced gray matter volume in the anterior cingulate gyrus, hippocampus, hippocampal gyrus and precuneus and cerebellum compared to controls. Moreover, gray matter volume in the right anterior cingulate gyrus was negatively correlated with the severity of depression. SBM results demonstrated that compared to healthy controls, individuals with MDD showed reduced cortical thickness in temporal pole, paracentral gyrus, angular gyrus and insula.
Conclusion: These findings suggest that structural alterations in the anterior cingulate gyrus are linked to MDD, thereby providing understanding into the neural mechanisms underlying MDD.
Application: Alterations in the anterior cingulate cortex may act as neuroimaging markers of MDD, and these findings provide a possibility to developed the diagnosis system for MDD.

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