김치에서 분리한 Lactobacillus plantarum AF1의 흰쥐에 대한 반복투여독성 (Repeated-Dose Oral Toxicity Study of Lactobacillus Plantarum AF1 Isolated from Kimchi in Rats)

서지정보

· 발행기관 : 한국식품영양과학회
· 수록지 정보 : 한국식품영양과학회지 / 41권 / 5호 / 612 ~ 620페이지
· 저자명 : 이재준, 김아라, 장해춘, 이명렬

초록

This study was performed to investigate the 4-week repeated-dose toxicity of Lactobacillus plantarum AF1 (Lb. plantarum AF1), a lactic acid bacteria isolated from kimchi, in male and female rats. Sprague-Dawley male and female rats were divided into four groups, with 10 animals in each group. The test article was administered once daily by gavage to rats at dosage levels of 0, 0.5, 1.0, and 2.0 g/kg/day for 4-weeks. There were no test article- related deaths or abnormal clinical signs in either gender of rat during the observation period. Furthermore, no differences were found between the control and treatment groups in terms of body weight changes, food intake, and water consumptions. Hematological parameters, serum biochemical analysis, and any other findings also showed no significant or dose-dependent alterations. There were no alterations in organ weights upon administration of Lb. plantarum AF1. These results suggest that there were no adverse effects of oral application of Lb. plantarum AF1 up to a dosage level of 2.0 g/kg in both male and female rats.

영어초록

This study was performed to investigate the 4-week repeated-dose toxicity of Lactobacillus plantarum AF1 (Lb. plantarum AF1), a lactic acid bacteria isolated from kimchi, in male and female rats. Sprague-Dawley male and female rats were divided into four groups, with 10 animals in each group. The test article was administered once daily by gavage to rats at dosage levels of 0, 0.5, 1.0, and 2.0 g/kg/day for 4-weeks. There were no test article- related deaths or abnormal clinical signs in either gender of rat during the observation period. Furthermore, no differences were found between the control and treatment groups in terms of body weight changes, food intake, and water consumptions. Hematological parameters, serum biochemical analysis, and any other findings also showed no significant or dose-dependent alterations. There were no alterations in organ weights upon administration of Lb. plantarum AF1. These results suggest that there were no adverse effects of oral application of Lb. plantarum AF1 up to a dosage level of 2.0 g/kg in both male and female rats.

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