자초(Lithospermum erythrorhizon) 추출물이 UVB로 조사된 생쥐 피부에 미치는 영향 (The Effect of Lithospermum erythrorhizon Extracts in UVB-Irradiated Mouse Skin)

서지정보

· 발행기관 : 한국현미경학회
· 수록지 정보 : Applied Microscopy / 38권 / 3호 / 195 ~ 204페이지
· 저자명 : 송선영

초록

This study was intended to identify the effectiveness of Lithospermum erythrorhizon in the UVB-irradiated mouse skin.
The C57BL mice were divided into three groups; the control group, the UVB irradiated group (UVB group), and the group
treated with Lithospermum erythrorhizon extracts after UVB irradiation (UVB+Le group). 10 mouses were collected and
sacrificed at 24 hrs, 48 hrs, 72 hrs, 120 hrs, and 168 hrs, respectively.
In the result, the transepidermal water loss (TEWL) was decreased the UVB+Le group than UVB groups by time. At
the 168 hrs group was significantly lower (p⁄0.05).
In the result, the melanin value was decreased in the UVB+Le group than UVB group, but meaningless (p¤0.05). In
the result of erythema index, the UVB+Le group was meaningfully lower at 24 hrs, 48 hrs, and 72 hrs group than UVB
group (p⁄0.05). In the result of scanning electron micrograph observation, the UVB+Le group was allevited swelling
than UVB group at the 24 hrs, formation of the scab at the 48 hrs, regular plate shap at the 72 hrs, new keratin observated
at the 120 hrs partially, and fine fiber covered epidermis surface at the 168 hrs.
In the result of transmission electron micrograph observation, the UVB+Le group was facilitation of increased lamellar
bodies and reformation lamellar bodies than UVB group at the all groups. Almost all the structures were recovered at
the 168 hrs group. In conclusion, Lithospermum erythema extracts may recovery on the UVB-irradiated mouse skin.

영어초록

This study was intended to identify the effectiveness of Lithospermum erythrorhizon in the UVB-irradiated mouse skin.
The C57BL mice were divided into three groups; the control group, the UVB irradiated group (UVB group), and the group
treated with Lithospermum erythrorhizon extracts after UVB irradiation (UVB+Le group). 10 mouses were collected and
sacrificed at 24 hrs, 48 hrs, 72 hrs, 120 hrs, and 168 hrs, respectively.
In the result, the transepidermal water loss (TEWL) was decreased the UVB+Le group than UVB groups by time. At
the 168 hrs group was significantly lower (p⁄0.05).
In the result, the melanin value was decreased in the UVB+Le group than UVB group, but meaningless (p¤0.05). In
the result of erythema index, the UVB+Le group was meaningfully lower at 24 hrs, 48 hrs, and 72 hrs group than UVB
group (p⁄0.05). In the result of scanning electron micrograph observation, the UVB+Le group was allevited swelling
than UVB group at the 24 hrs, formation of the scab at the 48 hrs, regular plate shap at the 72 hrs, new keratin observated
at the 120 hrs partially, and fine fiber covered epidermis surface at the 168 hrs.
In the result of transmission electron micrograph observation, the UVB+Le group was facilitation of increased lamellar
bodies and reformation lamellar bodies than UVB group at the all groups. Almost all the structures were recovered at
the 168 hrs group. In conclusion, Lithospermum erythema extracts may recovery on the UVB-irradiated mouse skin.

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