구기자와 구기엽이 난소적출 흰쥐의 간에 미치는 영향 (The Effects of Lycii fructus and Lycii folium on the Liver in Ovariectomized Rat)

서지정보

· 발행기관 : 한국현미경학회
· 수록지 정보 : Applied Microscopy / 38권 / 4호 / 353 ~ 361페이지
· 저자명 : 윤중식, 차영주, 김정상

초록

We aimed to investigate whether the extracts of Lycii fructus, Lycii folium, and estradiol can attenuate on the level of
cholesterol on serum and ultrastructure alteration of hepatocytes isolated from ovariectomized rats. Experimental groups
are divided into five: Sham (sham-operated), OVX (ovariectomized animal), LCF (OVX, Lycii fructus), LCL (OVX, Lycii
folium), and E2 (OVX, estradiol).
The body weights of OVX group showed increase compared with Sham, LCF, and LCL groups. The levels of total
cholesterol and low-density lipoprotein (LDL) cholesterol were significantly decreased in the LCF and LCL groups
compared with those of OVX group. Moreover, the High-density lipoprotein (HDL) cholesterol level was increased in the
LCL group. As the results of electron microscopical observation, lipid droplets in the OVX group showed increase compared
with Sham group. But in the LCF group not showed lipid droplets.
In conclusion, administration of Lycii fructus or Lycii folium lowers the serum cholesterol content of the ovariectomized
rats and also the damage of the hepatocytes and formation of lipid droplets.

영어초록

We aimed to investigate whether the extracts of Lycii fructus, Lycii folium, and estradiol can attenuate on the level of
cholesterol on serum and ultrastructure alteration of hepatocytes isolated from ovariectomized rats. Experimental groups
are divided into five: Sham (sham-operated), OVX (ovariectomized animal), LCF (OVX, Lycii fructus), LCL (OVX, Lycii
folium), and E2 (OVX, estradiol).
The body weights of OVX group showed increase compared with Sham, LCF, and LCL groups. The levels of total
cholesterol and low-density lipoprotein (LDL) cholesterol were significantly decreased in the LCF and LCL groups
compared with those of OVX group. Moreover, the High-density lipoprotein (HDL) cholesterol level was increased in the
LCL group. As the results of electron microscopical observation, lipid droplets in the OVX group showed increase compared
with Sham group. But in the LCF group not showed lipid droplets.
In conclusion, administration of Lycii fructus or Lycii folium lowers the serum cholesterol content of the ovariectomized
rats and also the damage of the hepatocytes and formation of lipid droplets.

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