흰쥐의 외과적 창상에 대한 야관문 에탄올 추출물의 피부재생 효과 (Regeneration Effects of Lespedeza cuneata Ethanol Extract on Experimental Open Wound in Rat)

서지정보

· 발행기관 : 한국식품영양과학회
· 수록지 정보 : 한국식품영양과학회지 / 43권 / 4호 / 516 ~ 521페이지
· 저자명 : 김대익, 김혜정

초록

야관문 추출물의 피부재생능력을 알아보고, 창상을 유발한실험동물 모델에서 창상 치유 효과를 검증하고자 6개 군(NO, CO, PC, LCL, LCM, LCH)으로 나누어 5주간 실험하였다. Elastase 저해 활성을 평가한 결과 LCM군에서 항산화제인 BHA보다 2.7%(52.39±4.52 vs 53.88±1.85) 낮은수치를 나타내었으며, collagenase 저해 활성을 평가한 결과 LCM군에서 BHA보다 7%(37.68±2.91 vs 35.19±7.80) 더 높은 활성을 나타내었다. 창상유발 21일에 LCL군, LCM 군 및 LCH군의 왼쪽 창상 면적은 CO군과 비교하여 각각54.2%, 53.5% 및 48.7% 현저한 창상면적 감소를 보였다.
이로서 야관문 추출물은 피부상피조직의 재생과 교원질의합성을 도와 외과적 창상에 치료 효과가 있는 것으로 판단된다.

영어초록

The purpose of this study was to examine the skin regeneration ability of Lespedeza cuneata extract (LC) as well as verify its wound healing effects on an open wound in rats. Rats were divided into six groups (NO, saline treated group; CO, 1% carboxy methyl cellulose (CMC) treated group; PC, fucidin treated group; LCL, 1% LC treated group; LCM, 3% LC treated group; LCH, 5% LC treated group), and the experimental material was applied for 5 weeks. Elastase inhibition rate of the LCM group was 2.7% lower than that of butylated hydroxy anisole (BHA), which is an antioxidant. Futher, the collagenase inhibition rate of the LCM showed 7% higher activity than that of BHA. The left wound areas in the LCL group, LCM group, and LCH group after the 21st day were noticeably reduced in wound area by 54.2%, 53.5%, and 48.7%, respectively, compared to the CO group. This suggests that Lespedeza cuneata extract has healing effects on surgical wounds by promoting regeneration of skin epithelial tissue and synthesis of collagen.

참고자료

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