근적외선 레이저 반응성 광열-기포 생성 알지네이트 나노입자로부터 제어된 약물 방출 (Near Infrared Laser-Responsive Photothermal Bubbling Alginate Nanoparticles for Controlled Drug Release)

서지정보

· 발행기관 : 한국키틴키토산학회
· 수록지 정보 : Journal of Chitin and Chitosan / 26권 / 3호 / 127 ~ 133페이지
· 저자명 : 김현지, 김민아, 이창문

초록

In order to maximize the therapeutic effect of a drug, it is necessary to control the release rate of the drug or efficiently deliver it to an accurate target site. In this study, alginate-melanin-methotrexate-perfluorohexane nanoparticles (AMP NPs) were proposed for controlling the drug release by near-infrared (NIR) laser-responsive photothermal- bubbling effect. AMP NPs had a uniform spherical shape with a size of 252.52 ± 0.39 nm and did not show precipitation in PBS buffer for 7 days. Based on the unique light-to-heat conversion properties of melanin, the temperature of AMP NPs rose to about 52.9°C after irradiation with an 808 nm NIR laser with an intensity of 1.5 W/cm2 for 10 min. As the exotherm of melanin reached the phase transition temperature of perfluorohexane (PFH), microbubbles from the AMP NPs solution were generated dramatically. The release rate of methotrexate from AMP NPs increased to 61% after 24 h of laser irradiation due to the heat generation of melanin and bubble generation of PFH in AMP NPs. From these results, it is expected that AMP NPs can be utilized as promising carriers for controlled drug release.

영어초록

In order to maximize the therapeutic effect of a drug, it is necessary to control the release rate of the drug or efficiently deliver it to an accurate target site. In this study, alginate-melanin-methotrexate-perfluorohexane nanoparticles (AMP NPs) were proposed for controlling the drug release by near-infrared (NIR) laser-responsive photothermal- bubbling effect. AMP NPs had a uniform spherical shape with a size of 252.52 ± 0.39 nm and did not show precipitation in PBS buffer for 7 days. Based on the unique light-to-heat conversion properties of melanin, the temperature of AMP NPs rose to about 52.9°C after irradiation with an 808 nm NIR laser with an intensity of 1.5 W/cm2 for 10 min. As the exotherm of melanin reached the phase transition temperature of perfluorohexane (PFH), microbubbles from the AMP NPs solution were generated dramatically. The release rate of methotrexate from AMP NPs increased to 61% after 24 h of laser irradiation due to the heat generation of melanin and bubble generation of PFH in AMP NPs. From these results, it is expected that AMP NPs can be utilized as promising carriers for controlled drug release.

참고자료

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