미숙아에서 따라 잡기 성장의 예측인자로서 출생 체중 Z-Score의 효용성 (The Usefulness of Birth Weight Z-Score as a Predictor of Catch Up Growth in Preterm Infants)

서지정보

· 발행기관 : 대한신생아학회
· 수록지 정보 : Neonatal medicine / 22권 / 3호 / 142 ~ 149페이지
· 저자명 : 박휘진, 이해연, 우혜경, 김선녀, 이주영, 양혜란, 김병일, 최창원

초록

Purpose: The aim of the study was to examine whether the degree of fetal smallness in small for gestational age (SGA) infants would increase the risk of catch-up-growth failure at 12 and 24 months corrected age (CA), and whether the high-calorie nutri- tional support would improve catch-up growth between 12 and 24 months CA.
Methods: We conducted a retrospective cohort study on 103 preterm infants born between January 2010 and December 2011. Logistic regression analysis was per- formed to investigate whether the birth weight z-score would be an independent risk factor for catch-up growth failure at 12 or 24 months CA. Among the 46 infants with failed catch-up growth at 12 months CA, 16 infants were provided high-calorie nutri- tional support, including nutritional supplements and medium chain triglyceride (MCT) oil at the pediatric gastroenterology clinic.
Results: Of 103 preterm infants, 34 infants (33%) were SGA and 69 infants (67%) were appropriate for gestational age (AGA). One birth weight z-score decrement increased the odds for catch-up growth failure 2.9 times at 12 months CA and 3.0 times at 24 months CA after adjustment for major neonatal morbidities. The increase in z-score between 12 and 24 months CA was significantly greater in the infants provided nutritional support than in the infants who were not provided nutritional support.
Conclusion: The birth weight z-score can be used as a predictor of catch-up growth failure. High-calorie nutritional support may improve weight gain during the second year in preterm infants with failed catch-up growth at 12 months CA.

영어초록

Purpose: The aim of the study was to examine whether the degree of fetal smallness in small for gestational age (SGA) infants would increase the risk of catch-up-growth failure at 12 and 24 months corrected age (CA), and whether the high-calorie nutri- tional support would improve catch-up growth between 12 and 24 months CA.
Methods: We conducted a retrospective cohort study on 103 preterm infants born between January 2010 and December 2011. Logistic regression analysis was per- formed to investigate whether the birth weight z-score would be an independent risk factor for catch-up growth failure at 12 or 24 months CA. Among the 46 infants with failed catch-up growth at 12 months CA, 16 infants were provided high-calorie nutri- tional support, including nutritional supplements and medium chain triglyceride (MCT) oil at the pediatric gastroenterology clinic.
Results: Of 103 preterm infants, 34 infants (33%) were SGA and 69 infants (67%) were appropriate for gestational age (AGA). One birth weight z-score decrement increased the odds for catch-up growth failure 2.9 times at 12 months CA and 3.0 times at 24 months CA after adjustment for major neonatal morbidities. The increase in z-score between 12 and 24 months CA was significantly greater in the infants provided nutritional support than in the infants who were not provided nutritional support.
Conclusion: The birth weight z-score can be used as a predictor of catch-up growth failure. High-calorie nutritional support may improve weight gain during the second year in preterm infants with failed catch-up growth at 12 months CA.

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