Succinylcholine 투여 후 나타나는 속상수축을 감소시키기 위한 적절한 Rocuronium의 용량 (Optimal Priming Dose of Rocuronium for Prevention of Succinylcholine Induced Fasciculations)

서지정보

· 발행기관 : 대한마취통증의학회
· 수록지 정보 : Anesthesia and Pain Medicine / 2권 / 3호 / 122 ~ 125페이지
· 저자명 : 허민정

초록

Background: Subparalyzing dose of nondepolarizing muscle
relaxants is often given prior to succinylcholine to reduce its adverse
effects. At the same time, priming dose may worsen the intubating
condition due to its antagonizing effect at neuromuscular junction.
Although optimal priming dose of rocuronium is known to 0.03 0.04
mg/kg but higher priming dose may reduce interval from priming
drug to succinylcholine. This study was designed to determine the
maximal priming dose of rocuronium.
Methods: Sixty ASA I or II adult patients were randomized into
three groups: group R1 received 0.06 mg/kg of rocuronium, group
R2, 0.09 mg/kg and group Scc, normal saline. About 3 minutes
after priming dose, thiopental 4 mg/kg, fentanyl 1μg/kg and
succinylcholine 2 mg/kg were administered for anesthesia induction.
The presence and severity of fasciculations and intubating conditions
were evaluated with the incidence of side effects.
Results: In preventing fasciculations, group R1 and R2 were
significantly better than group Scc, without significant difference
between group R1 and R2. Intubation conditions were significantly
worse in group R2 than in group Scc.
Conclusions: The maximal priming dose of rocuronium to prevent
fasciculations and optimizing intubating condition was 0.06 mg/kg.

영어초록

Background: Subparalyzing dose of nondepolarizing muscle
relaxants is often given prior to succinylcholine to reduce its adverse
effects. At the same time, priming dose may worsen the intubating
condition due to its antagonizing effect at neuromuscular junction.
Although optimal priming dose of rocuronium is known to 0.03 0.04
mg/kg but higher priming dose may reduce interval from priming
drug to succinylcholine. This study was designed to determine the
maximal priming dose of rocuronium.
Methods: Sixty ASA I or II adult patients were randomized into
three groups: group R1 received 0.06 mg/kg of rocuronium, group
R2, 0.09 mg/kg and group Scc, normal saline. About 3 minutes
after priming dose, thiopental 4 mg/kg, fentanyl 1μg/kg and
succinylcholine 2 mg/kg were administered for anesthesia induction.
The presence and severity of fasciculations and intubating conditions
were evaluated with the incidence of side effects.
Results: In preventing fasciculations, group R1 and R2 were
significantly better than group Scc, without significant difference
between group R1 and R2. Intubation conditions were significantly
worse in group R2 than in group Scc.
Conclusions: The maximal priming dose of rocuronium to prevent
fasciculations and optimizing intubating condition was 0.06 mg/kg.

참고자료

· 없음