인플루엔자 바이러스에 대한 Zanthoxylum속의 항바이러스 효과 검정

서지정보

· 발행기관 : 한국약용작물학회
· 수록지 정보 : 한국약용작물학회지 / 16권 / 4호 / 273 ~ 278페이지
· 저자명 : 최화정, 송재형, 권두한, 백승화, 안용준

초록

We aimed to investigate the antiviral activity of Zanthoxylum species against influenza virus A/WS/33, A/PR/
8 and B/Lee/40 used by sulforhodamine B (SRB) assay and the action of leaves extracts of Zanthoxylum piperitum on life
cycle of influenza virus A/WS/33. Among the twelve extracts, only the leaf extract of Z. piperitum exhibited strong antiviral
activity at low concentration of less than 10㎍/㎖ with no citotoxicity (50㎍/㎖) against all of three viruses. In addition, only
oseltamivir showed antiviral activity with IC50 of 65.3㎍/㎖ against influenza A/WS/33 among the viruses. Furthermore, the
leaf extract of Z. piperitum suppressed infection of influenza virus A/WS/33, when added just prior (−1 hr) or after virus
inoculation (0 hr). Leaf extract of Z. piperitum directly affect the infectivity of influenza virus A/WS/33 particles. Therefore,
Leaf extract of Z. piperitum exhibited higher antiviral activity against three influenza viruses than that of the oseltamivir,
which directly interacts with influenza A/WS/33 particles, affecting the initial stages of infection such as receptor binding
and virus entry.

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