당뇨흰쥐의 콜라겐 감소 및 인간 피부 섬유아세포의MMP-1 증가에 대한 牧丹皮의 항피부노화 효과 (Anti-skin-aging effects of Paeonia Suffruticosa Andrews on maintaining skin collagen in STZ-induced diabetic rats and inhibiting MMP-1 systhesis in human skin fibroblasts)

서지정보

· 발행기관 : 대한한방안이비인후피부과학회
· 수록지 정보 : 한방안이비인후피부과학회지 / 21권 / 1호 / 1 ~ 15페이지
· 저자명 : 김경진, 김경준

초록

Objective : Skin aging is commonly observed in patients with diabetes mellitus, which can be accessed
by the amount of skin collagen and matrix metalloproteinase-1 (MMP-1). In the present study, anti-skin-aging
effects of Root Cortex of Paeonia Suffruticosa Andrews (PSA), which has been widely used to treat diabetes
mellitus, are investigated.
Methods : Streptozotocin (STZ) was intraperitoneally injected to rats to induce diabetes. Body weights, feed intake,
organ weights, blood glucose, and other biochemical index are determined in both normal and diabetic rats. In order
to study the effect of PSA on skin aging, the amount of skin collagen was measured in diabetic rats after PSA
treatments. Also, MMP-1 synthesis in UVB-irradiated human skin fibroblasts was investigated.
Results : 1. When PSA was administered to STZ-induced diabetic rats, feed intake was significantly increased and
blood glucose and total cholesterol were decreased in a dose-dependent manner. However, there are no
differences in individual organ weights, GOT, and GPT.
2. A decrease of skin collagen in diabetic rats was significantly suppressed when PSA was treated.
3. PSA also inhibited MMP-1 synthesis in UVB-irradiated normal human skin fibroblasts, similar to
retinoid, a well-known effective anti-skin-aging substance.
Conclusion: PSA suppressed a collagen decrease in diabetic rats and inhibited MMP-1 synthesis in UVB-irradiated
human skin fibroblasts. Therefore, the treatment of PSA is very effective to slow down the skin aging process.

영어초록

Objective : Skin aging is commonly observed in patients with diabetes mellitus, which can be accessed
by the amount of skin collagen and matrix metalloproteinase-1 (MMP-1). In the present study, anti-skin-aging
effects of Root Cortex of Paeonia Suffruticosa Andrews (PSA), which has been widely used to treat diabetes
mellitus, are investigated.
Methods : Streptozotocin (STZ) was intraperitoneally injected to rats to induce diabetes. Body weights, feed intake,
organ weights, blood glucose, and other biochemical index are determined in both normal and diabetic rats. In order
to study the effect of PSA on skin aging, the amount of skin collagen was measured in diabetic rats after PSA
treatments. Also, MMP-1 synthesis in UVB-irradiated human skin fibroblasts was investigated.
Results : 1. When PSA was administered to STZ-induced diabetic rats, feed intake was significantly increased and
blood glucose and total cholesterol were decreased in a dose-dependent manner. However, there are no
differences in individual organ weights, GOT, and GPT.
2. A decrease of skin collagen in diabetic rats was significantly suppressed when PSA was treated.
3. PSA also inhibited MMP-1 synthesis in UVB-irradiated normal human skin fibroblasts, similar to
retinoid, a well-known effective anti-skin-aging substance.
Conclusion: PSA suppressed a collagen decrease in diabetic rats and inhibited MMP-1 synthesis in UVB-irradiated
human skin fibroblasts. Therefore, the treatment of PSA is very effective to slow down the skin aging process.

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