대사증후군과 전립샘비대증: 대사증후군 개별요소와 전립샘용적, 전립샘특이항원의 상관관계를 통한 고찰 (Metabolic Syndrome and Benign Prostatic Hyperplasia: A Study Focused on the Correlation between Metabolic Syndrome Factors and Prostate Volume and Prostate-specific Antigen)

서지정보

· 발행기관 : 대한비뇨의학회
· 수록지 정보 : Investigative and Clinical Urology / 49권 / 11호 / 986 ~ 991페이지
· 저자명 : 장택환, 손정환, 김재일, 장석흔

초록

Purpose: To evaluate the relationship between metabolic syndrome and benign prostatic hyperplasia in Korean men, we investigated the relation between prostate volume and the serum prostate specific-antigen (PSA) level with the factors for metabolic syndrome.
Materials and Methods: We reviewed the data of 1,412 men who had a general health check-up without significant evidence of disease between January 2004 and May 2007. The age, prostate volume, PSA, PSA density and metabolic factors were measured, and the relationships of these factors were evaluated. We also compared the prostate-related data between the metabolic syndrome(MS) group and non-metabolic syndrome(NMS) group.
Results: The prostate volume was significantly larger in the MS group (23.0±7.1ml) than that in the NMS group(20.9±6.1ml)(p＜0.001). There was no statistically significant difference of the PSA level between the two groups(MS group: 0.86±0.66, NMS group: 0.90±0.81), but the PSAD was significantly different between the two groups(MS group: 0.038±0.027, NMS group: 0.044±0.031)(p=0.0035). We concluded that there was a significant correlation between the prostate volume and the metabolic syndrome factors. However, when analyzing the influence of each metabolic syndrome factor on the prostate volume, only the BMI was a relatively influential factor.
Conclusions: Our study showed that there was significant correlation between each metabolic syndrome factor and the prostate volume. This seemed to be the result of the commonly related pathophysiology of MS and an enlarged prostrate volume, and obesity was a significant factor. It was meaningful that the PSA level in the MS group was lower than that of the NMS group in case of the same prostate volume.

영어초록

Purpose: To evaluate the relationship between metabolic syndrome and benign prostatic hyperplasia in Korean men, we investigated the relation between prostate volume and the serum prostate specific-antigen (PSA) level with the factors for metabolic syndrome.
Materials and Methods: We reviewed the data of 1,412 men who had a general health check-up without significant evidence of disease between January 2004 and May 2007. The age, prostate volume, PSA, PSA density and metabolic factors were measured, and the relationships of these factors were evaluated. We also compared the prostate-related data between the metabolic syndrome(MS) group and non-metabolic syndrome(NMS) group.
Results: The prostate volume was significantly larger in the MS group (23.0±7.1ml) than that in the NMS group(20.9±6.1ml)(p＜0.001). There was no statistically significant difference of the PSA level between the two groups(MS group: 0.86±0.66, NMS group: 0.90±0.81), but the PSAD was significantly different between the two groups(MS group: 0.038±0.027, NMS group: 0.044±0.031)(p=0.0035). We concluded that there was a significant correlation between the prostate volume and the metabolic syndrome factors. However, when analyzing the influence of each metabolic syndrome factor on the prostate volume, only the BMI was a relatively influential factor.
Conclusions: Our study showed that there was significant correlation between each metabolic syndrome factor and the prostate volume. This seemed to be the result of the commonly related pathophysiology of MS and an enlarged prostrate volume, and obesity was a significant factor. It was meaningful that the PSA level in the MS group was lower than that of the NMS group in case of the same prostate volume.

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