가교 atenolol 각인 키토산 기반 바이오 패치 제조 및 평가 (Preparation and Characterization of Crosslinked Atenolol ImprintedChitosan-based Biomaterial Patches)

서지정보

· 발행기관 : 한국키틴키토산학회
· 수록지 정보 : Journal of Chitin and Chitosan / 24권 / 2호 / 110 ~ 116페이지
· 저자명 : 김한성, 심왕근, 윤순도

초록

The main objects of this work are to prepare the functional crosslinked chitosan(CH)-based biomaterial patches imprinted with atenolol (ATN) as the target drug. The crosslinked CH-based biomaterial patches were synthesized by casting method and UV curing process. Physical properties such as tensile strength (TS), elongation at break (%E), degree of swelling (DS), solubility (S) for prepared biomaterial patches were investigated. In addition, the surface morphology of the biomaterials was characterized by scanning electron microscope (SEM). To evaluate the binding characteristics of prepared functional biomaterial patches added with/without the addition of ATN, the adsorption properties of the prepared films was investigated by equilibrium binding experiment. The results of the evaluation analysis indicate that the prepared functional biomaterial patches have the binding site for ATN as the target molecule. The ATN release for the transdermal patch was examined with pH and temperature. In addition, the release of ATN was carried out by using artificial skin. From the results, it could be verified that the prepared functional biomaterial patches can be applied in functional medical patches.

영어초록

The main objects of this work are to prepare the functional crosslinked chitosan(CH)-based biomaterial patches imprinted with atenolol (ATN) as the target drug. The crosslinked CH-based biomaterial patches were synthesized by casting method and UV curing process. Physical properties such as tensile strength (TS), elongation at break (%E), degree of swelling (DS), solubility (S) for prepared biomaterial patches were investigated. In addition, the surface morphology of the biomaterials was characterized by scanning electron microscope (SEM). To evaluate the binding characteristics of prepared functional biomaterial patches added with/without the addition of ATN, the adsorption properties of the prepared films was investigated by equilibrium binding experiment. The results of the evaluation analysis indicate that the prepared functional biomaterial patches have the binding site for ATN as the target molecule. The ATN release for the transdermal patch was examined with pH and temperature. In addition, the release of ATN was carried out by using artificial skin. From the results, it could be verified that the prepared functional biomaterial patches can be applied in functional medical patches.

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