당뇨병성 심혈관계 합병증과 관련된 생체표지자의 임상적 의의 (Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications)

서지정보

· 발행기관 : 대한당뇨병학회
· 수록지 정보 : Diabetes and Metabolism Journal / 33권 / 5호 / 363 ~ 372페이지
· 저자명 : 손장원, 권혁상

초록

Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most
associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque
rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are
coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative
stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis.
Diabetes is also associated with hypercoaguable states and endothelial injury. Hyperactivated platelets at
injured endothelial surfaces act together due to the increased availability of thrombotic precursors and
diminished fibrinolysis. Advances in the understanding of the pathogenesis of atherosclerosis associated with
diabetes have yielded new hypotheses regarding the links between risk factors and the cellular and
molecular alterations that underlie cardiovascular disease. Recently, there has been increasing interest in
utilizing novel biomarkers of cardiovascular disease risk that have the potential to be useful indicators for
better risk assessment, diagnosis, and prognosis. However, to date, most conventional and emerging
biomarkers have only modest predictive values, and there remains a need to identify additional biomarkers
using new biological approaches. This review highlights the clinical implications of emerging biomarkers
associated with cardiovascular disease in patients with diabetes and recent developments in new technologies
for the identification of biomarkers.

영어초록

Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most
associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque
rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are
coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative
stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis.
Diabetes is also associated with hypercoaguable states and endothelial injury. Hyperactivated platelets at
injured endothelial surfaces act together due to the increased availability of thrombotic precursors and
diminished fibrinolysis. Advances in the understanding of the pathogenesis of atherosclerosis associated with
diabetes have yielded new hypotheses regarding the links between risk factors and the cellular and
molecular alterations that underlie cardiovascular disease. Recently, there has been increasing interest in
utilizing novel biomarkers of cardiovascular disease risk that have the potential to be useful indicators for
better risk assessment, diagnosis, and prognosis. However, to date, most conventional and emerging
biomarkers have only modest predictive values, and there remains a need to identify additional biomarkers
using new biological approaches. This review highlights the clinical implications of emerging biomarkers
associated with cardiovascular disease in patients with diabetes and recent developments in new technologies
for the identification of biomarkers.

참고자료

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