수혈 부작용 예방을 위한 백혈구 제거 혈액 필터의 제조와 성능평가 (Manufacturing and Performance Evaluation of Leukocyte Removal Blood Filter to Prevent Adverse Blood Transfusion)

서지정보

· 발행기관 : 한국섬유공학회
· 수록지 정보 : 한국섬유공학회지 / 56권 / 5호 / 285 ~ 292페이지
· 저자명 : 이경태, 홍영기

초록

Recently, the number of blood transfusion patients has been on the rise, and various side effects have been reported. These side effects are mainly caused by leukocytes, and they can be prevented if the amount of leukocytes in blood products is reduced by 80−90% or more. In this study, melt-blown (M/B) manufacturing process conditions were adjusted internally using the pore size, and a composite blood filter was manufactured using spun-bond (S/B) externally. In pig blood, performance evaluations were conducted on various leukocyte reduction filters developed to prevent the side effects of transfusion.
The leukocyte removal filters were evaluated by analyzing the scanning electron microscopic (SEM) images, mean pore diameter (MPD), contact angle measurement, and leukocyte rejection. Consequently, the filters that were used in this experiment had contact angles of about 15−20o and leukocyte rejection rates of 32−99%. The stable performance of the filter was confirmed in pig blood. Therefore, the M/B filter can potentially be applied as a leukocyte removal filter.

영어초록

Recently, the number of blood transfusion patients has been on the rise, and various side effects have been reported. These side effects are mainly caused by leukocytes, and they can be prevented if the amount of leukocytes in blood products is reduced by 80−90% or more. In this study, melt-blown (M/B) manufacturing process conditions were adjusted internally using the pore size, and a composite blood filter was manufactured using spun-bond (S/B) externally. In pig blood, performance evaluations were conducted on various leukocyte reduction filters developed to prevent the side effects of transfusion.
The leukocyte removal filters were evaluated by analyzing the scanning electron microscopic (SEM) images, mean pore diameter (MPD), contact angle measurement, and leukocyte rejection. Consequently, the filters that were used in this experiment had contact angles of about 15−20o and leukocyte rejection rates of 32−99%. The stable performance of the filter was confirmed in pig blood. Therefore, the M/B filter can potentially be applied as a leukocyte removal filter.

참고자료

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