줄딸기 열수 추출물이 고지방 식이를 급여한 흰쥐의 지질대사와 항산화에 미치는 효과 (Effect of Water Extract from Rubus oldhamii Miq. on Lipid Metabolism and Antioxidant Activity in Rats Fed High Fat Diet)

서지정보

· 발행기관 : 한국지역사회생활과학회
· 수록지 정보 : 한국지역사회생활과학회지 / 30권 / 3호 / 341 ~ 350페이지
· 저자명 : 원향례

초록

The aim of this study was to observe the biological activity of Rubus oldhamii Miq. and assess the possibility of using it as a new natural functional material. The effects of a Rubus oldhamii Miq. water extract on the lipid metabolism of white rats fed a normal or high fat diet were examined. The Rubus oldhamii Miq. water extract (300 mg/kg) was given to Sprague Dawley male white rats for four weeks given normal or high fat diets to determine its effect on the lipid composition and antioxidant activity. The results are as follows. The food intakes were similar in all groups, but the weight gain (p<0.05) and food efficiency ratio (p<0.05) was low in the normal group supplemented with Rubus oldhamii Miq. extract. When the normal diet was supplemented with the Rubus oldhamii Miq. water extract, the triglyceride decreased (p<0.05), and the total cholesterol and LDL-cholesterol decreased significantly in the high fat diet (p<0.05). When Rubus oldhamii Miq. water extract was added to the high fat diet, the glutathione peroxidase activity was significantly high in the blood, and glutathione reductase activity was significantly high in the liver(p<0.05). The quantity of MDA generated, which is the peroxide of blood and liver, showed a declining trend in all of the groups supplemented with the Rubus oldhamii Miq. water extract. When Rubus oldhamii Miq. water extract was supplemented in the normal diet, the triglyceride content decreased significantly (p<0.05), and the total cholesterol and LDL-cholesterol decreased significantly in the high fat diet (p<0.05).
The total cholesterol in the liver decreased significantly in the high fat diet supplemented with Rubus oldhamii Miq. water extract (p<0.05). Accordingly, when the Rubus oldhamii Miq. water extract is supplemented in a high fat diet, it reduces the lipid in blood and liver to improve the lipid metabolism efficiently. In addition, because it is a water extract, it might be useful as a safe food material.

영어초록

The aim of this study was to observe the biological activity of Rubus oldhamii Miq. and assess the possibility of using it as a new natural functional material. The effects of a Rubus oldhamii Miq. water extract on the lipid metabolism of white rats fed a normal or high fat diet were examined. The Rubus oldhamii Miq. water extract (300 mg/kg) was given to Sprague Dawley male white rats for four weeks given normal or high fat diets to determine its effect on the lipid composition and antioxidant activity. The results are as follows. The food intakes were similar in all groups, but the weight gain (p<0.05) and food efficiency ratio (p<0.05) was low in the normal group supplemented with Rubus oldhamii Miq. extract. When the normal diet was supplemented with the Rubus oldhamii Miq. water extract, the triglyceride decreased (p<0.05), and the total cholesterol and LDL-cholesterol decreased significantly in the high fat diet (p<0.05). When Rubus oldhamii Miq. water extract was added to the high fat diet, the glutathione peroxidase activity was significantly high in the blood, and glutathione reductase activity was significantly high in the liver(p<0.05). The quantity of MDA generated, which is the peroxide of blood and liver, showed a declining trend in all of the groups supplemented with the Rubus oldhamii Miq. water extract. When Rubus oldhamii Miq. water extract was supplemented in the normal diet, the triglyceride content decreased significantly (p<0.05), and the total cholesterol and LDL-cholesterol decreased significantly in the high fat diet (p<0.05).
The total cholesterol in the liver decreased significantly in the high fat diet supplemented with Rubus oldhamii Miq. water extract (p<0.05). Accordingly, when the Rubus oldhamii Miq. water extract is supplemented in a high fat diet, it reduces the lipid in blood and liver to improve the lipid metabolism efficiently. In addition, because it is a water extract, it might be useful as a safe food material.

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