노즐 이송 방식 딥코팅 시스템을 활용한 장형 다공성 인조혈관 제작 (Fabrication of Long Porous Vascular Grafts Using Nozzle-Transfer Dip-Coating System)

서지정보

· 발행기관 : 한국기계가공학회
· 수록지 정보 : 한국기계가공학회지 / 22권 / 7호 / 11 ~ 19페이지
· 저자명 : 이승문, 김영서, 박석희

초록

Dip-coating methods, in conjunction with 3D printing and particle leaching, provide a promising approach forfabricating artificial vascular grafts with enhanced mechanical and biocompatible properties through theincorporation of porous structures. However, the current limitations of the dip-coating process hinder thefabrication of long vascular grafts suitable for femoral artery treatment. These limitations include therequirement of a solution tank deeper than the length of template and an excessive amount of coatingsolution. Moreover, the extended exposure time of the pre-formed porous structure to the coating solutionduring the multi-coating process often leads to significant damage. To address these challenges, we developeda novel coating system that utilized a moving nozzle containing coating solution, thereby significantlyreducing the amount of solution required. Furthermore, the developed system minimized the exposure time ofthe porous structure to the coating solution. We employed the appropriately sized nozzle to prevent theleakage of coating solution through the gap between the template and the nozzle during the process.
Additionally, we determined the optimal nozzle transfer rate to achieve uniform coating thickness.
Consequently, this approach enabled the fabrication of long porous artificial vascular grafts, specificallyexceeding 30cm in length, with internal porous structures that potentially improved biocompatibility whilemaintaining coating uniformity.

영어초록

Dip-coating methods, in conjunction with 3D printing and particle leaching, provide a promising approach forfabricating artificial vascular grafts with enhanced mechanical and biocompatible properties through theincorporation of porous structures. However, the current limitations of the dip-coating process hinder thefabrication of long vascular grafts suitable for femoral artery treatment. These limitations include therequirement of a solution tank deeper than the length of template and an excessive amount of coatingsolution. Moreover, the extended exposure time of the pre-formed porous structure to the coating solutionduring the multi-coating process often leads to significant damage. To address these challenges, we developeda novel coating system that utilized a moving nozzle containing coating solution, thereby significantlyreducing the amount of solution required. Furthermore, the developed system minimized the exposure time ofthe porous structure to the coating solution. We employed the appropriately sized nozzle to prevent theleakage of coating solution through the gap between the template and the nozzle during the process.
Additionally, we determined the optimal nozzle transfer rate to achieve uniform coating thickness.
Consequently, this approach enabled the fabrication of long porous artificial vascular grafts, specificallyexceeding 30cm in length, with internal porous structures that potentially improved biocompatibility whilemaintaining coating uniformity.

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