사염화탄소 투여로 인한 랫드의 급성 간 손상에 대한 루틴의 예방 효과 (Protective Effect of Rutin on Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats)

서지정보

· 발행기관 : 한국임상수의학회
· 수록지 정보 : 한국임상수의학회지 / 30권 / 1호 / 12 ~ 16페이지
· 저자명 : 황의경

초록

This study was performed to investigate hepatoprotective effect of rutin on acute hepatic damage induced by carbon tetrachloride in rats. Twenty-four male Sprague-Dawley rats were randomly divided into four groups; normal control group, CCl4 control group, two rutin treatment groups (rutin 200+CCl4 and rutin 400+CCl4). Dissolving vehicles were applied to the rats in the normal control group. The rutin was administrated to the rats in rutin 200+CCl4 and rutin 400+CCl4 groups at the levels of 200 mg/kg and 400 mg/kg, 3 consecutive days orally, with 24 hours interval before inoculating CCl4. CCl4 was intraperitoneally administered an hour after the last treatment of rutin to the rats in every group except the normal control group. The body weight of rats in CCl4 control group were significantly lower than other groups (p < 0.05), but the liver weight and relative liver weight were higher than normal control group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in sera of rats in CCl4control group were higher and the levels of total protein, albumin and globulin were lower than the normal group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in rutin 200+CCl4 and rutin 400+CCl4 groups were lower than CCl4 control group (p < 0.05). Therefore the pre-treatment of rutin before CCl4inoculation in rats effectively inhibited the elevation of serum ALT, AST and total bilirubin which are the parameters of hepatic damage.

영어초록

This study was performed to investigate hepatoprotective effect of rutin on acute hepatic damage induced by carbon tetrachloride in rats. Twenty-four male Sprague-Dawley rats were randomly divided into four groups; normal control group, CCl4 control group, two rutin treatment groups (rutin 200+CCl4 and rutin 400+CCl4). Dissolving vehicles were applied to the rats in the normal control group. The rutin was administrated to the rats in rutin 200+CCl4 and rutin 400+CCl4 groups at the levels of 200 mg/kg and 400 mg/kg, 3 consecutive days orally, with 24 hours interval before inoculating CCl4. CCl4 was intraperitoneally administered an hour after the last treatment of rutin to the rats in every group except the normal control group. The body weight of rats in CCl4 control group were significantly lower than other groups (p < 0.05), but the liver weight and relative liver weight were higher than normal control group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in sera of rats in CCl4control group were higher and the levels of total protein, albumin and globulin were lower than the normal group (p < 0.05). The activities of ALT, AST, ALP, GTP, LDH and the level of total bilirubin in rutin 200+CCl4 and rutin 400+CCl4 groups were lower than CCl4 control group (p < 0.05). Therefore the pre-treatment of rutin before CCl4inoculation in rats effectively inhibited the elevation of serum ALT, AST and total bilirubin which are the parameters of hepatic damage.

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