다형성 선종과 선양낭성 암종에서 상피성장인자 발현에 관한 연구 (The study of EGF expression between human pleomorphic adenoma and adenoid cystic carcinoma)

서지정보

· 발행기관 : 대한구강악안면외과학회
· 수록지 정보 : 대한구강악안면외과학회지 / 34권 / 3호 / 245 ~ 249페이지
· 저자명 : 박승구, 한세진, 김철환, 김경욱

초록

Epidermal growth factor is a single-chain polypeptide consisting of 53 amino acids and has a potent mitogenic activity that stimulates proliferation
of various normal and neoplastic cells through the interaction with its specific receptor(epidermal growth factor receptor, EGFR).
Pleomorphic adenoma is the most common salivary benign tumor and histologically, it contains the epithelial cell, the myo-epithelial cell and mesenchymal
ingredient, which is various aspect. Adenoid cystic carcinoma is an infiltrative malignant salivary gland tumor with three different histological
patterns: cribriform, tubular or solid. The tumor cell structure composed of modified myoepithelial cell, and basaloid cell. In this study, we used an
immunohistochemical technique to investigate the expression of EGF in 6 specimens of adenoid cystic carcinoma and 10 specimens of pleomorphic
adenoma taken from patients treated at Dept. of Oral and Maxillofacial Surgery, Dankook University.
The results were as follows.
1. In pleomorphic adenoma, ductal structure and scattered spindle cells in hyalinized stroma, disclosing myxoid stroma and hyalin, cartilage formation
were observed. Immunohistologically, weak EGF expression in ductal structure and negative in stromal area were observed.
2. Cribriform type of adenoid cystic carcinoma showed numerous pseudocyst surrounded by dark small neoplastic cells in the back-ground of
fibrous connective tissue and moderate EGF expression of dark cells adjacent to pseudo lumen in cribriform pattern, while weak expression in
other most cells.
3. Tubular type of adenoid cystic carcinoma showed numerous ductal pattern surrounded by two layered neoplastic cells in the back-ground of
fibrous connective tissue and strong EGF expression in luminal cells of ductal structure, while weak expression in outer cells.
From the results obtained, we suggest that EGF is mainly biosynthesized in cells forming duct like structures of tubulo-ductal type or cribriform
adenoid cystic carcinoma and it may play a role, as a cell mitogen in adenoid cystic carcinoma growth.

영어초록

Epidermal growth factor is a single-chain polypeptide consisting of 53 amino acids and has a potent mitogenic activity that stimulates proliferation
of various normal and neoplastic cells through the interaction with its specific receptor(epidermal growth factor receptor, EGFR).
Pleomorphic adenoma is the most common salivary benign tumor and histologically, it contains the epithelial cell, the myo-epithelial cell and mesenchymal
ingredient, which is various aspect. Adenoid cystic carcinoma is an infiltrative malignant salivary gland tumor with three different histological
patterns: cribriform, tubular or solid. The tumor cell structure composed of modified myoepithelial cell, and basaloid cell. In this study, we used an
immunohistochemical technique to investigate the expression of EGF in 6 specimens of adenoid cystic carcinoma and 10 specimens of pleomorphic
adenoma taken from patients treated at Dept. of Oral and Maxillofacial Surgery, Dankook University.
The results were as follows.
1. In pleomorphic adenoma, ductal structure and scattered spindle cells in hyalinized stroma, disclosing myxoid stroma and hyalin, cartilage formation
were observed. Immunohistologically, weak EGF expression in ductal structure and negative in stromal area were observed.
2. Cribriform type of adenoid cystic carcinoma showed numerous pseudocyst surrounded by dark small neoplastic cells in the back-ground of
fibrous connective tissue and moderate EGF expression of dark cells adjacent to pseudo lumen in cribriform pattern, while weak expression in
other most cells.
3. Tubular type of adenoid cystic carcinoma showed numerous ductal pattern surrounded by two layered neoplastic cells in the back-ground of
fibrous connective tissue and strong EGF expression in luminal cells of ductal structure, while weak expression in outer cells.
From the results obtained, we suggest that EGF is mainly biosynthesized in cells forming duct like structures of tubulo-ductal type or cribriform
adenoid cystic carcinoma and it may play a role, as a cell mitogen in adenoid cystic carcinoma growth.

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