비기능성 뇌하수체 선종의 경접형동 뇌하수체 종양 절제술 후 뇌하수체 호르몬 변화 (Pituitary Hormonal Changes after Transsphenoidal Tumor Removal in Non-Functioning Pituitary Adenoma)

서지정보

· 발행기관 : 대한내분비학회
· 수록지 정보 : Endocrinology and Metabolism / 24권 / 3호 / 181 ~ 188페이지
· 저자명 : 이민석, 한승진, 김은경, 황주안, 정윤석, 김세혁, 조경기, 임내정, 김호성

초록

Background: The present study investigated the rates and the potential predictors of either new pituitary loss or recovery of hormonal function after transsphenoidal removal of a non-functioning pituitary adenoma.
Methods: Patients who underwent transsphenoidal removal of a non-functioning pituitary adenoma from January 2003 to December 2007 at Ajou University Medical Center were included in this retrospective analysis. Patients were excluded if they had a history of previous pituitary tumor surgery, or did not have preoperative pituitary hormonal data.
Results: Of 42 patients included in the analysis, 36 patients had hypopituitarism, 21 patients had “stalk compression” hyperprolactinemia, and 2 patients had normal pituitary function. At long term follow-up (longer than 6 months), 13 patients showed postoperative pituitary hormonal recovery in at least 1 hormonal axis, while 6 patients had developed postoperative hormonal loss in at least 1 hormonal axis. On analysis, neither preoperative serum prolactin level nor tumor size was related to postoperative pituitary hormonal changes.
Conclusion: More than 1/3 of patients who underwent transsphenoidal surgery showed postoperative pituitary hormonal recovery.

영어초록

Background: The present study investigated the rates and the potential predictors of either new pituitary loss or recovery of hormonal function after transsphenoidal removal of a non-functioning pituitary adenoma.
Methods: Patients who underwent transsphenoidal removal of a non-functioning pituitary adenoma from January 2003 to December 2007 at Ajou University Medical Center were included in this retrospective analysis. Patients were excluded if they had a history of previous pituitary tumor surgery, or did not have preoperative pituitary hormonal data.
Results: Of 42 patients included in the analysis, 36 patients had hypopituitarism, 21 patients had “stalk compression” hyperprolactinemia, and 2 patients had normal pituitary function. At long term follow-up (longer than 6 months), 13 patients showed postoperative pituitary hormonal recovery in at least 1 hormonal axis, while 6 patients had developed postoperative hormonal loss in at least 1 hormonal axis. On analysis, neither preoperative serum prolactin level nor tumor size was related to postoperative pituitary hormonal changes.
Conclusion: More than 1/3 of patients who underwent transsphenoidal surgery showed postoperative pituitary hormonal recovery.

참고자료

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