현미경 진단용 슬라이드 제작을 위한 단층세포 흡착장치 개발 (Development of Mono Layer Cell Adsorption Apparatus to Create a Slide for Microscopic Diagnosis)

서지정보

· 발행기관 : 대한의용생체공학회
· 수록지 정보 : 의공학회지 / 36권 / 1호 / 1 ~ 6페이지
· 저자명 : 오한영, 문민기, 김성현, 김동욱, 강소미, 성락경, 김현창

초록

This study aims to design a monolayer cell adsorption apparatus that would help to produce high-qualityslides for Liquid-Based Cytology (LBC) of an early cancer diagnosis for human bodies. The LBC collects exfoliatedcells of human bodies and spreads the cells on the slides. Through processes of dyeing and cytological examination,the LBC screens for cancers in early stage. In this study, both of a cell suction module and a cell adsorption module,which are the key elements of the monolayer cell adsorption apparatus, were developed, and using those modules,the study set, first, conditions to help both GYN and NON-GYN apply principal cells without de-endothelializationbefore conducting its own analysis on the utility. As a results, for GYN, apparatus was determined to be able to producehigh-quality slides under the condition of 4 and for NON-GYN, the apparatus would come up with other slidesof high-quality under the condition of 2. The study carried out a repetitive test on selected conditions and proved96% of the repetitive success rate. By the results of what has been learned so far, the study presents that the apparatushas a possibility to replace device from South Korea as one of those other currently-applied systems to runthe LBC and that the system will also present a new paradigm for cancer diagnosis as it makes a contribution tothe improvement in the LBC.

영어초록

This study aims to design a monolayer cell adsorption apparatus that would help to produce high-qualityslides for Liquid-Based Cytology (LBC) of an early cancer diagnosis for human bodies. The LBC collects exfoliatedcells of human bodies and spreads the cells on the slides. Through processes of dyeing and cytological examination,the LBC screens for cancers in early stage. In this study, both of a cell suction module and a cell adsorption module,which are the key elements of the monolayer cell adsorption apparatus, were developed, and using those modules,the study set, first, conditions to help both GYN and NON-GYN apply principal cells without de-endothelializationbefore conducting its own analysis on the utility. As a results, for GYN, apparatus was determined to be able to producehigh-quality slides under the condition of 4 and for NON-GYN, the apparatus would come up with other slidesof high-quality under the condition of 2. The study carried out a repetitive test on selected conditions and proved96% of the repetitive success rate. By the results of what has been learned so far, the study presents that the apparatushas a possibility to replace device from South Korea as one of those other currently-applied systems to runthe LBC and that the system will also present a new paradigm for cancer diagnosis as it makes a contribution tothe improvement in the LBC.

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