꽃송이버섯 추출물의 간세포에서 대사 활성 효과 (The Metabolic Activity of Sparassis crispa Extract in Hepatocytes)

서지정보

· 발행기관 : 한국생물공학회
· 수록지 정보 : KSBB Journal / 35권 / 2호 / 150 ~ 156페이지
· 저자명 : 백소정, 조남준, 조성진, 김은미, 김기광

초록

Sulfonylurea treatment is used for diabetes mellitus, a metabolic disease caused by abnormal absorption of glucose in the body. But it is accompanied by side effects in vivo when taken for a long time. Therefore, there is a need for research on natural materials having similar effects to these therapeutic agents and having fewer side effects that can effectively regulate blood sugar. In this study, we investigated the antioxidative efficacy of Sparassis crispa (S. crispa) extract and the activity of ATP, glycolysis, and mitochondrial membrane potential using human hepatocyte HepG2 cells. As a result, S. crispa extract showed high antioxidant activity and induced a significant increase in HepG2 cell activity and ATP production. S. crispa extract also significantly accelerated the process and mitochondrial membrane potential. Taken together, these results suggest that S. crispa extract has the potential to be developed as a natural material for improving diabetic and diabetic complications by activating hepatic energy metabolism.

영어초록

Sulfonylurea treatment is used for diabetes mellitus, a metabolic disease caused by abnormal absorption of glucose in the body. But it is accompanied by side effects in vivo when taken for a long time. Therefore, there is a need for research on natural materials having similar effects to these therapeutic agents and having fewer side effects that can effectively regulate blood sugar. In this study, we investigated the antioxidative efficacy of Sparassis crispa (S. crispa) extract and the activity of ATP, glycolysis, and mitochondrial membrane potential using human hepatocyte HepG2 cells. As a result, S. crispa extract showed high antioxidant activity and induced a significant increase in HepG2 cell activity and ATP production. S. crispa extract also significantly accelerated the process and mitochondrial membrane potential. Taken together, these results suggest that S. crispa extract has the potential to be developed as a natural material for improving diabetic and diabetic complications by activating hepatic energy metabolism.

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