제조업 근로자들의 혈청 Perfluorooctanoic Acid (PFOA) 농도와 생활습관 및 직업적 관련요인 (Lifestyle and Work related Factors Associated with Serum PFOA among Workers at Manufacturing Companies)

서지정보

· 발행기관 : 대한직업환경의학회
· 수록지 정보 : Annals of Occupational and Environmental Medicine / 20권 / 3호 / 233 ~ 244페이지
· 저자명 : 장상환, 김대환, 김권복, 안진홍, 김휘동, 이창희, 김정호, 이종태, 이채관

초록

Objectives: The objective of this study was to determine serum perfluorooctanoic acid (PFOA) concentrations
and to investigate the relationship of lifestyle, health status and work-related factors among
workers at manufacturing companies with possible occupational exposure to PFOA.
Methods: The study subjects were 315 workers (male 203, female 112) of manufacturing companies
with possible exposure to PFOA from August to December, 2007. A questionnaire was administered to
investigate lifestyle and work-related factors. Serum PFOA concentrations were analyzed by LCMS/
MS, and liver function and total cholesterol were also tested.
Results: Serum PFOA concentrations ranged from 1.0 to 40.9 ng/mL (mean 8.0 ng/mL). Serum PFOA
concentrations increased with age. Male workers had higher PFOA concentration than female workers
(male 9.0 ng/mL; female 6.3 ng/mL). According to stepwise multiple regression analysis, factors significantly
associated with PFOA concentration were male, being older, higher total cholesterol, and lower
body mass index. Adjusted for age and gender by logistic regression, dyeing and finishing textiles had
significantly higher odds ratio (OR) of 6.16, and moulding patterns, moulds and industrial patterns
(OR=4.84), sections for ships (OR=3.87), and plastics synthetic leather (OR=10.05) had marginally significantly
high odds ratios.
Conclusions: This study demonstrated the factors affecting serum PFOA concentration of workers at
manufacturing companies. Further study is needed to ensure the effect of occupational exposure on
serum PFOA concentration.

영어초록

Objectives: The objective of this study was to determine serum perfluorooctanoic acid (PFOA) concentrations
and to investigate the relationship of lifestyle, health status and work-related factors among
workers at manufacturing companies with possible occupational exposure to PFOA.
Methods: The study subjects were 315 workers (male 203, female 112) of manufacturing companies
with possible exposure to PFOA from August to December, 2007. A questionnaire was administered to
investigate lifestyle and work-related factors. Serum PFOA concentrations were analyzed by LCMS/
MS, and liver function and total cholesterol were also tested.
Results: Serum PFOA concentrations ranged from 1.0 to 40.9 ng/mL (mean 8.0 ng/mL). Serum PFOA
concentrations increased with age. Male workers had higher PFOA concentration than female workers
(male 9.0 ng/mL; female 6.3 ng/mL). According to stepwise multiple regression analysis, factors significantly
associated with PFOA concentration were male, being older, higher total cholesterol, and lower
body mass index. Adjusted for age and gender by logistic regression, dyeing and finishing textiles had
significantly higher odds ratio (OR) of 6.16, and moulding patterns, moulds and industrial patterns
(OR=4.84), sections for ships (OR=3.87), and plastics synthetic leather (OR=10.05) had marginally significantly
high odds ratios.
Conclusions: This study demonstrated the factors affecting serum PFOA concentration of workers at
manufacturing companies. Further study is needed to ensure the effect of occupational exposure on
serum PFOA concentration.

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