경북대_2023_1_생화학2

경북대_2023_1_생화학2_중간

문서 내 토픽

1. oligosaccharide

우리몸이 사용하는 형태의 당은 monosaccharide이다. 탄수화물은 하이드록실기를 가진 탄소화합물로, monosaccharide는 한개의 비대칭중심에서 배열이 다른 당이다. 미생물의 세포벽을 이루는 아미노산은 L폼이 아닌 D폼인데, 이는 protease에 의해 분해되는 것을 막기 위해서이다. 당은 cyclic form과 sugar alcohol 형태로 존재하며, pyranose와 furanose 구조를 가진다. UV 조사로 인한 base damage가 발생할 수 있다.
2. monosaccharide

monosaccharide는 6탄 당으로 존재하며, 이당류 및 단당류로 분해된다. 구강 내 amylase에 의해 dextrose glucose로 분해되며, 이당류로는 sucrose, lactose, maltose가 있다. 단당류로는 glucose, fructose, galactose 등이 있다.
3. carbohydrate

탄수화물은 다양한 이성질체 형태로 존재하며, 분자식은 같지만 원자 배열이 다른 입체이성질체가 있다. 탄수화물은 환원성과 비환원성 형태로 존재하며, 리보솜에서 단백질 합성 시 에너지원으로 사용된다.
4. glycosidic bond

탄수화물은 glycosidic bond를 통해 결합하며, N-linked와 O-linked 결합 형태가 있다. 미생물 내부에서는 D-형태의 당이 주로 존재한다.
5. glycoprotein

당단백질은 진핵세포의 ER과 골지체에서 합성되며, 3가지 형태(cis, media, trans)로 존재한다. 당단백질은 세포막, 세포외기질, 혈액형 등에 관여한다.
6. lipid

지질은 동물에 포함된 대표적인 중성지방이며, 탄수화물의 아노머 C원자와 알코올의 하이드록실 O원자 간 결합으로 이루어진다. 지질은 세포막, 호르몬, 비타민 등에 관여한다.
7. protein

단백질은 아미노산이 peptide bond로 결합된 고분자 화합물이다. 단백질 합성 시 리보솜에서 GTP가 사용된다. 단백질은 효소, 구조단백질, 수송단백질 등의 기능을 한다.
8. membrane

세포막은 인지질 이중층 구조로 되어있으며, 단백질이 삽입되어 있다. 세포막은 유동성, 비대칭성, 전기적 극성을 가지며, 세포 내외부를 구분한다.
9. signal transduction

세포 내 신호전달 과정에서 1차 신호전달물질(ligand)이 수용체에 결합하면 2차 신호전달물질(cAMP, Ca2+)이 활성화되어 생리적 반응을 일으킨다. 이 과정은 G-단백질, 단백질 인산화 효소 등이 관여한다.
10. insulin signaling

인슐린 신호전달 경로에서 인슐린이 수용체에 결합하면 IRS-1, IRS-2가 활성화되고 PI3-kinase, Akt 등의 단계를 거쳐 최종적으로 대사 및 성장 반응이 일어난다. 이 과정에서 phosphate의 이동이 중요하다.

Easy AI와 토픽 톺아보기

1. oligosaccharide

Oligosaccharides are complex carbohydrates composed of a small number of monosaccharide units linked together by glycosidic bonds. They play important roles in various biological processes, such as cell-cell recognition, cell signaling, and immune system regulation. Oligosaccharides can be found on the surface of cells, where they serve as receptors for pathogens, and in glycoproteins, where they contribute to the protein's structure and function. Understanding the structure and function of oligosaccharides is crucial for developing new therapeutic approaches, such as the design of anti-adhesion drugs that can prevent pathogen binding to host cells. Additionally, oligosaccharides have potential applications in the food and cosmetic industries, as they can be used as prebiotics, emulsifiers, and moisturizers.
2. monosaccharide

Monosaccharides are the simplest form of carbohydrates, serving as the building blocks for more complex carbohydrates, such as oligosaccharides and polysaccharides. They are classified based on the number of carbon atoms they contain and the presence of a carbonyl group. Monosaccharides play crucial roles in various biological processes, including energy production, cell signaling, and structural support. Glucose, fructose, and galactose are examples of common monosaccharides that are essential for human health. Understanding the properties and functions of monosaccharides is fundamental to our understanding of carbohydrate metabolism and the development of therapies for carbohydrate-related diseases, such as diabetes. Additionally, monosaccharides have applications in the food, pharmaceutical, and chemical industries, where they are used as sweeteners, precursors for the synthesis of other compounds, and building blocks for the production of more complex carbohydrates.
3. carbohydrate

Carbohydrates are a class of macromolecules that play essential roles in various biological processes, including energy production, structural support, and cell signaling. They are composed of carbon, hydrogen, and oxygen atoms, and can be classified into different types, such as monosaccharides, disaccharides, and polysaccharides, based on their structural complexity. Carbohydrates are a primary source of energy for many organisms, and they are also involved in the regulation of gene expression, immune function, and neurological processes. Understanding the structure and function of carbohydrates is crucial for the development of new therapeutic approaches, such as the design of glycomimetic drugs and the development of carbohydrate-based vaccines. Additionally, carbohydrates have numerous applications in the food, pharmaceutical, and chemical industries, where they are used as sweeteners, thickeners, and building blocks for the synthesis of other compounds.
4. glycosidic bond

Glycosidic bonds are covalent linkages that connect monosaccharide units to form more complex carbohydrate structures, such as oligosaccharides and polysaccharides. These bonds are formed through a condensation reaction between the hydroxyl group of one monosaccharide and the anomeric carbon of another monosaccharide, resulting in the release of a water molecule. Glycosidic bonds play a crucial role in the structural and functional diversity of carbohydrates, as they determine the branching patterns, linkage types, and overall conformation of the carbohydrate molecules. Understanding the formation and properties of glycosidic bonds is essential for understanding the biological functions of carbohydrates, such as their roles in cell-cell recognition, cell signaling, and immune system regulation. Additionally, the ability to selectively cleave or form glycosidic bonds is a key aspect of carbohydrate chemistry and has important applications in the development of new therapeutic agents, such as glycosidase inhibitors and glycomimetic drugs.
5. glycoprotein

Glycoproteins are a class of macromolecules that consist of a protein covalently linked to one or more oligosaccharide chains. These glycosidic modifications play a crucial role in the structure, function, and localization of the protein. Glycoproteins are found on the surface of cells, where they serve as receptors for various ligands, and in the extracellular matrix, where they contribute to cell-cell and cell-matrix interactions. They are also involved in a wide range of biological processes, including cell signaling, immune system regulation, and protein folding and trafficking. Understanding the structure and function of glycoproteins is essential for the development of new therapeutic approaches, such as the design of glycomimetic drugs and the development of glycoprotein-based vaccines. Additionally, glycoproteins have numerous applications in the biotechnology and pharmaceutical industries, where they are used as diagnostic markers, therapeutic agents, and research tools.
6. lipid

Lipids are a diverse class of biomolecules that play essential roles in various biological processes, including energy storage, cell membrane structure and function, and cell signaling. They are characterized by their hydrophobic nature and can be classified into different categories, such as fatty acids, triglycerides, phospholipids, and steroids. Lipids are crucial components of cell membranes, where they provide a barrier to the passage of water-soluble molecules and facilitate the transport of nutrients, ions, and signaling molecules. They are also involved in the regulation of gene expression, the modulation of enzyme activity, and the maintenance of cellular homeostasis. Understanding the structure and function of lipids is essential for the development of new therapeutic approaches, such as the design of lipid-based drug delivery systems and the treatment of lipid-related disorders, such as cardiovascular disease and metabolic syndromes. Additionally, lipids have numerous applications in the food, cosmetic, and chemical industries, where they are used as emulsifiers, lubricants, and raw materials for the synthesis of other compounds.
7. protein

Proteins are large, complex biomolecules that play a fundamental role in virtually every biological process. They are composed of amino acids linked together by peptide bonds and can adopt a wide range of three-dimensional structures, which determine their specific functions. Proteins are involved in a vast array of biological activities, including catalyzing chemical reactions, transporting and storing other molecules, providing structural support, and regulating gene expression and cell signaling. Understanding the structure and function of proteins is crucial for the development of new therapeutic approaches, such as the design of targeted drugs and the engineering of novel enzymes and antibodies. Additionally, proteins have numerous applications in the biotechnology, pharmaceutical, and food industries, where they are used as therapeutic agents, diagnostic tools, and food additives. The study of proteins is a rapidly evolving field that continues to yield new insights into the fundamental mechanisms of life and the potential for innovative applications in various domains.
8. membrane

Biological membranes are essential components of all living cells, serving as a barrier that separates the internal environment of the cell from the external environment. They are composed primarily of lipids and proteins, which work together to regulate the movement of molecules, maintain cellular homeostasis, and facilitate various cellular processes. Membranes play a crucial role in a wide range of biological functions, including signal transduction, energy production, and cell-cell communication. Understanding the structure and function of biological membranes is essential for the development of new therapeutic approaches, such as the design of membrane-targeting drugs and the engineering of artificial cells and organelles. Additionally, membranes have numerous applications in the biotechnology and pharmaceutical industries, where they are used in the production of biofuels, the purification of proteins, and the development of drug delivery systems. The study of biological membranes continues to be an active area of research, with ongoing discoveries that expand our understanding of the fundamental mechanisms of life.
9. signal transduction

Signal transduction is the process by which cells convert extracellular stimuli into intracellular signals, enabling them to respond appropriately to their environment. This process involves a complex network of signaling pathways that involve various biomolecules, such as receptors, enzymes, and second messengers. Signal transduction is crucial for the regulation of a wide range of cellular processes, including cell growth, differentiation, metabolism, and apoptosis. Understanding the mechanisms of signal transduction is essential for the development of new therapeutic approaches, such as the design of targeted drugs that can modulate specific signaling pathways. Additionally, signal transduction has numerous applications in the fields of biotechnology and systems biology, where it is used to study the complex interactions between different cellular components and to develop computational models of cellular behavior. The study of signal transduction is an active area of research, with ongoing discoveries that continue to expand our understanding of the fundamental mechanisms of cellular communication and regulation.
10. insulin signaling

Insulin signaling is a complex and highly regulated process that plays a crucial role in the maintenance of glucose homeostasis and the regulation of various metabolic processes. This signaling pathway involves the binding of insulin to its receptor on the cell surface, which triggers a cascade of intracellular events that ultimately lead to the regulation of glucose uptake, glycogen synthesis, and lipid metabolism. Disruptions in insulin signaling are associated with the development of various metabolic disorders, such as type 2 diabetes, insulin resistance, and obesity. Understanding the mechanisms of insulin signaling is essential for the development of new therapeutic approaches, such as the design of insulin sensitizers, insulin mimetics, and targeted therapies for insulin-related diseases. Additionally, insulin signaling has numerous applications in the fields of endocrinology, pharmacology, and systems biology, where it is used to study the complex interactions between different cellular components and to develop computational models of metabolic regulation. The study of insulin signaling is an active area of research, with ongoing discoveries that continue to expand our understanding of the fundamental mechanisms of glucose homeostasis and metabolic regulation.
11. membrane

Biological membranes are essential components of all living cells, serving as a barrier that separates the internal environment of the cell from the external environment. They are composed primarily of lipids and proteins, which work together to regulate the movement of molecules, maintain cellular homeostasis, and facilitate various cellular processes. Membranes play a crucial role in a wide range of biological functions, including signal transduction, energy production, and cell-cell communication. Understanding the structure and function of biological membranes is essential for the development of new therapeutic approaches, such as the design of membrane-targeting drugs and the engineering of artificial cells and organelles. Additionally, membranes have numerous applications in the biotechnology and pharmaceutical industries, where they are used in the production of biofuels, the purification of proteins, and the development of drug delivery systems. The study of biological membranes continues to be an active area of research, with ongoing discoveries that expand our understanding of the fundamental mechanisms of life.