Use of T Cell–Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts

소개

연세대학교 의과대학 3학년 소아과학 실습중에 발표한 논문입니다.
2009년 논문이고 영어로 script를 적어두었습니다.
최근 화제가 되고 있는 ELISPOT를 통한 TST 결과 해석문제에 대해 논의한 논문(Clin Infect Dis. 2009 Feb 1;48(3):302-12)을 발표용 ppt로 만들었습니다.
Oxford에서 제작한 presentation용 script자료를 토대로 만들었으니 많은 활용바랍니다.

목차

Introduction
Materials and Methods
Results
Discussion
Conclusion

본문내용

*Background
Children with Mycobacterium tuberculosis infection are at high risk of developing active tuberculosis. As Infected children aged younger than 2 years have a 20% risk of progression to active disease, early diagnosis and treatment with Isoniazid is essential.
But, diagnosis is hindered by the inaccuracy of the tuberculin skin test .
For that reason, authors used more accurate T cell-based test of infection to enhance diagnosis by optimizing interpretation of the TST results.

*Materials and Methods
Study participants
Clinical evaluation
TST
Ex vivo IFN-g ELISPOT
Statistical methods

참고자료

· Use of T cell-based diagnosis of tuberculosis infection to optimize interpretation of tuberculin skin testing for child tuberculosis contacts. Clin Infect Dis. 2009 Feb 1;48(3):302-12