코팅 비드의 고상연화제로써 이부프로펜의 영향

소개

이부프로펜을 연화제로 사용하였을때 고분자 비드표면에서의 약물 방출 거동을
조사한 논문의 프레젠테이션 자료입니다.
아래는 논문제목입니다.

목차

The objectives
MATERIALS AND METHODS
Preparation of film-coating dispersion
Film coating of beads

본문내용

The objectives
were to investigate and characterize the drug release behavior and stability of beads coated with Eudragit RS 30 D containing ibuprofen as a multifunctional agent (active agent, plasticizer, and stabilizer) and to study the interaction between Eudragit RS 30 D and ibuprofen.


Aqueous film-coating dispersions
1. polymeric colloidal particles
2. plasticizer
3. pigment
4. anti-adherent agent

Most polymers employed for the film coating of pellets and tablets
1. brittle at room temperature
2. require the use of plasticizers to improve their handling  and processing

These plasticizing compounds
1. reduce the brittleness
2. increase the flexibility
3. improve the toughness and tensile strength of polymers.

The efficiency of a plasticizer
1. Chemical structure
2. extent of interaction with the polymer


However, many of these plasticizers have aging and
sticking problems when used for aqueous film
Coating, Mechanical changes in the film
coating may occur, especially during the coating
process and drying stages.

Temperature and moisture may damage many of the polymers currently used in pharmaceutical film coating and ultimately result in
changes in the dissolution properties of the drug.

참고자료

· Chuanbin Wu and James W. McGinity, I"nfluence of Ibuprofen as a Solid-State Plasticizer in Eudragit® RS 30 D on the Physicochemical Properties of Coated Beads", AAPS PharmSciTech 2001; 2 (4) article 24