colorectal cancer 대장암 발병기전 및 마우스모델 (all 영어)

목차

1. CRC
1) Definition
2) Incidence
3) Type & Stage
4) Treatment
5) Risk Factors

2. Pathogenesis
1) Chromosomal Instability
2) Microsatellite Instability

3. Mouse Models
1) Chemical Induced Model
2) Genetically Engineered Mouse Model
3) Transplant Model
4) Measurement

4. Recent & Future
1) Humanized mouse
2) Organoid

5. Researches
1) Microbiome & Immunotherapy

본문내용

1. Colorectal Cancer (CRC)
Definition
Disease in which malignant cells form in the tissues of the colon or rectum
Start as a polyps on the inner lining of the colon or rectum

Stage
- Adenocarcinoma (95%)
- Angiosarcoma
- GIST (gastrointestinal stromal tumor)
- Lymphoma

참고자료

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· Mouse Models for Cancer Immunotherapy Research. Cancer Discov November 1 2018 (8) (11) 1358-1365; DOI: 10.1158/2159-8290.CD-18-0044
· Mouse models of intestinal cancer. J. Pathol., 238: 141-151. https://doi.org/10.1002/path.4645
· The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models. Animal Model Exp Med. 2020; 3: 1–https://doi.org/10.1002/ame2.12102
· The Journal of Medicine and Life Science Vol. 15, No. 2, 42-45, December 2018 https://doi.org/10.22730/jmls.2018.15.2.42 ISSN: 1738-1010
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· Doi: 10.18632/oncoscience.59. PMID: 25594038; PMCID: PMC4284625.
· J Korean Soc Coloproctol 2005;21:433-444
· Korean J Med 79:113-118, 2010
· The path to metastatic mouse models of colorectal cancer. Oncogene 37, 2481–2489 (2018). https://doi.org/10.1038/s41388-018-0155-x
· Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models. Cells. 2019; 8(8):889.
· Gut microbiome and cancer immunotherapy, Cancer Letters, Volume 447, 2019, Pages 41-47, ISSN 0304-3835, https://doi.org/10.1016/j.canlet.2019.01.015.
· The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy. Cancer Cell. 2018 Apr 9;33(4):570-580. doi: 1016/j.ccell.2018.03.015. PMID: 29634945; PMCID: PMC6529202.
· The Impact of Intratumoral and Gastrointestinal Microbiota on Systemic Cancer Therapy. Trends Immunol. 2018 Nov;39(11):900-920. doi: 10.1016/j.it.2018.09.007. PMID: 30392721.