용해도(solubility)를 증강시키기 위해 산업에서 실용화되고 있는 기술

소개

서울대학교 약학대학 석사과정학생입니다.
약학대학 내 수업때 발표했던 발표자료입니다. 28장의 슬라이드로 구성되어 있으며 제약분야에서 solubility가 중요한 이유와 solubility를 증강시키기 위해 현재 산업에서 실용화되고 있는 기술들을 적었습니다.
그림과 설명을 자세히 적어 넣어 이해하기 쉽습니다.

목차

What do we mean by the term Solubility?

Solubilization technologies
About the drug
Prodrug
Particle size reduction
About formulation
Complexation
Carrier-mediated

Conclusion

Refference

본문내용

Supercritical fluid technologies are one of the brand new technology
supercritical fluid is any substance at a temperature and pressure above its critical point, where distinct liquid and gas phases do not exist
so, it has both of properties in gas and liquid
it’s density is very similar to liquids so the solubilities of solutes can increased

참고자료

· Anil K. Singla, 2001, International Journal of Pharmaceutics
· M. Narender Reddy et. Al, 2004, AAPS PharmSci
· Robert G. Strickley et. Al, 2004, Pharmaceutical Research
· Swati Rawat et. Al, 2004, European Journal of Pharmaceutics and Biopharmaceutics
· Thorsteinn loftsson et. Al, 1996, journal of the pharmaceutical sciences
· Varun Raj Vemula et. Al , 2010, International Journal of Pharmaceutical Sciences Review and Research
· Valentino J Stella, 2009, Arden Conference
· Valentino J. Stella et. al, 2007, Advanced Drug Delivery Reviews
· Vasu Kumar Kakumanu et. Al, 2004, BUSINESS BRIEFING:LABTECH
· Wikepedia : Solubility, Micelle
· Cernevit prescription