Stem cell based regeneration technology-줄기세포기반의 재생기술

소개

서울대학교 약학대학 물리약학과에서 물리약학특론수업 발표했던 내용입니다.
줄기세포를 기반으로하는 조직재생술의 현황과 이용에 대하여 내용이 구성되어있습니다.
PPT 20장여로 구성되어 있으며 질문과 답변 그리고 슬라이드노트가 영문으로 작성되어있습니다.

목차

1. Introduction-What is the stem cell?
2. classification of stem cell
3. adult stem cell
4. embryonic stem cell
5. iPS(induced pluripotent stemcell)
6. application
7. Q&A

본문내용

1. Embryonic Stem cell
2. Adult stem cell
Kind of Stem cell
Stem cells derived from the epiblast tissue of the inner cell mass (ICM) of a blastocyst
Advantage
Pluripotent
About 200 cells = Theoretical 200 tissues
Disadvantage
Ethical Problems
5 days after fertilization
at organism is Human?)
Immune Response
From other person
Embryonic stem cell for therapy
are found
Blood
Hematopoietic stem cells, Bone marrow stromal cells
Brain
Hippocampus, Subventricular Zone (SVZ)


..<중략>..

14
The more try is going on cardiac cells
As you seen in here the key factor to induce iPs to cardiac muscle is identified
So I think that shortly there are some result that differentiate to specific cell from iPS
15
But there are some obstacles to overcome in iPS
To make higher efficiency viral vectors are used in variously
But as you know that transfection serious problem in a safety aside because gene is integrated randomly. For this reason there are some try to transfection with a plasmid vector however efficiency is very low like 0.1%
Another problem is Myc gene which is transfected into somatic cell is a proto oncogene
That means it can inducing cancer so stem cell develop as cancer cell
More severe problem is there are only iPS cells coming from embryonic somatic cells yet.
And there are more than 100 clinical try in adult stem cell but there’s no try in iPS
Because iPS is kind of new strategy to using stem cell so it have to studied more detailed

참고자료

· 최근동향 5년내 논문발표내용을 기초로 작성