학동기 천식에서 성인 초기까지 천식의 지속에 미치는인자들 : 폐기능 및 기관지 과민성을 중심으로 (The Risk Factors for Persistence of Asthma Symptoms fromLate Childhood to Early Adult Life: The Effects of PulmonaryFunction and Bronchial Hyperresponsiveness)

서지정보

· 발행기관 : 대한 소아알레르기 호흡기학회
· 수록지 정보 : Allergy Asthma & Respiratory Disease / 18권 / 2호 / 29 ~ 38페이지
· 저자명 : 박종진, 김재진, 강임주

초록

Purpose:We performed this study to evaluate the effect of pulmonary function and bronchial hyperresponsiveness (BHR) on the persistence of asthma symptoms from late childhood to early adult life.
Methods:One-hundred thirty-one children with asthma treated at our hospital during the past 10 years were divided into 2 groups according to the persistence of symptoms in early adult life: the persistent and remission groups. Information about symptoms, body mass index, serum ECP, serum IgE and skin test reactivity in late childhood were obtained and prebronchodilator FEV1, FEV1/FVC (expressed as % of predicted) and BHR to methacholine were measured in late childhood and early adult life, and compared the 2 groups.
Results:The persistent group was accounted for 45.8% of the subjects and FEV1, FEV1/ FVC and BHR to methacholine in late childhood were associated with the persistence of symptoms. We found a positive correlation between FEV1 in late childhood and early adult.(r=0.250, P=0.013) Also we found a positive correlation between FEV1/FVC in late childhood and early adult.(r=0.285, P=0.018) BHR and FEV1% of 60% to 79% of late childhood were associated with BHR in early adult.(Odds ratio; 95% confidence interval=3.8; 1.7-8.7, 4.6; 1.0-20.2)
Conclusion:Low pulmonary function and increased BHR in childhood asthma were associated with persistence of symptom, degree of pulmonary function and BHR in early adult life.

영어초록

Purpose:We performed this study to evaluate the effect of pulmonary function and bronchial hyperresponsiveness (BHR) on the persistence of asthma symptoms from late childhood to early adult life.
Methods:One-hundred thirty-one children with asthma treated at our hospital during the past 10 years were divided into 2 groups according to the persistence of symptoms in early adult life: the persistent and remission groups. Information about symptoms, body mass index, serum ECP, serum IgE and skin test reactivity in late childhood were obtained and prebronchodilator FEV1, FEV1/FVC (expressed as % of predicted) and BHR to methacholine were measured in late childhood and early adult life, and compared the 2 groups.
Results:The persistent group was accounted for 45.8% of the subjects and FEV1, FEV1/ FVC and BHR to methacholine in late childhood were associated with the persistence of symptoms. We found a positive correlation between FEV1 in late childhood and early adult.(r=0.250, P=0.013) Also we found a positive correlation between FEV1/FVC in late childhood and early adult.(r=0.285, P=0.018) BHR and FEV1% of 60% to 79% of late childhood were associated with BHR in early adult.(Odds ratio; 95% confidence interval=3.8; 1.7-8.7, 4.6; 1.0-20.2)
Conclusion:Low pulmonary function and increased BHR in childhood asthma were associated with persistence of symptom, degree of pulmonary function and BHR in early adult life.

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