八味合聰明湯 열수추출물, 초미세분말제형이 Alzheimer's Disease 병태 모델에 미치는 영향 (The Effects of PalMihapChongMungTang(PMCMT) Hot Water Extract & Ultra-fine Powder on the Alzheimer's Disease Model)

서지정보

· 발행기관 : 대한한방신경정신과학회
· 수록지 정보 : 동의신경정신과학회지 / 19권 / 2호 / 95 ~ 110페이지
· 저자명 : 임정화, 이상룡

초록

Objective :
This experiment was designed to investigate the effects of the PMCMT hot water extract & ultra-fine powder on Alzheimer's Disease Model Induced by βA.

Method :
The effects of the PMCMT hot water extract on expression of proinflammatory cytokine mRNA in BV2 microglial cell cell line treated by lipopolysacchaide(LPS).
The effects of the PMCMT hot water extract & ultra-fine powder on (1) the behavior (2) AChE in serum (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with βA were investigated.

Result :
1. The PMCMT hot water extract suppressed the expression of proinflammatory cytokine mRNA in BV2 microglial cell line treated with LPS.
2. The PMCMT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency
3. The PMCMT hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer's disease induced by βA.
5. The PMCMT ultra-fine powder reduced infarction area of hippocampus significantly, and the PMCMT hot water extract & ultra-fine powder controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA.

Conclusions :
These results suggest that the PMCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the PMCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

영어초록

Objective :
This experiment was designed to investigate the effects of the PMCMT hot water extract & ultra-fine powder on Alzheimer's Disease Model Induced by βA.

Method :
The effects of the PMCMT hot water extract on expression of proinflammatory cytokine mRNA in BV2 microglial cell cell line treated by lipopolysacchaide(LPS).
The effects of the PMCMT hot water extract & ultra-fine powder on (1) the behavior (2) AChE in serum (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with βA were investigated.

Result :
1. The PMCMT hot water extract suppressed the expression of proinflammatory cytokine mRNA in BV2 microglial cell line treated with LPS.
2. The PMCMT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency
3. The PMCMT hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer's disease induced by βA.
5. The PMCMT ultra-fine powder reduced infarction area of hippocampus significantly, and the PMCMT hot water extract & ultra-fine powder controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA.

Conclusions :
These results suggest that the PMCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the PMCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

참고자료

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