육미지황탕(환)의 약리와 독성에 대한 문헌고찰 (Pharmacological and Toxicological review of Yukmijihwang-tang(Hwan))

서지정보

· 발행기관 : 대한한의학방제학회
· 수록지 정보 : 대한한의학 방제학회지 / 20권 / 1호 / 13 ~ 24페이지
· 저자명 : 박영철, 김종봉, 국윤범, 이선동

초록

육미지황환(또는 육미지황탕)은 1,119년 소아약증직결에서 지황환이라는 처방이름으로 전을에 의해 처음으로 제시되었다(http://home.comcast.net). 육미지황환의 구성 한약재는 숙지황, 산약, 산수유, 목단피, 택사, 백복령의 6가지이다1). 그러나 오늘날 한약재의 구성이 변경되면서 여러 목적으로 응용되고 있다. 특히 중의약에서는 Zhibai Dihuang Wan, Guifu Dihuang Wan,, Mingmu Dihuang Wan, Qiju Dihuang Wan, Maiwei Dihuang Wan과 Guishao Dihuang Wan 등 수 백가지 처방이 새로이 만들어졌다. 육미지환환의 한약재 구성의 이러한 다양한 변화는 우수한 약리효능에 기인한다. 특히 우리나라에서는 육미지황환을 신장의 음을 보충하는 목적으로 사용한다1). 오늘날 연구를 통해 육미지황환은 신장기능, 면역조절, 혈당감소 및 당뇨병, 고혈압 및 고지혈, 심혈관질환 등의 약리효능이 있는 것이 확인되고 있다2-5,11,13). 이러한 육미지황환에 대한 약리기전과 더불어 한약에 대한 안전성에 대한 연구가 진행되고 있다6-7). 본 논문에서는 육미지황환에 대한 새로운 약리효능 및 안전성과 더불어 임상응용에 대한 연구사례에 대해서 고찰하였다.

영어초록

Objectives : Yukmijihwang-tang(Wan), a well-known formula for invigorating yin-particular kidney yin, was first recorded in “Xiao er Yao Zheng Zhi Jue”, consisting of Radix Rehmanniae Preparata, Fructus Macrocarpii, Rhizoma Dioscoreae Oppositae, Poria, Rhizoma Alismatis and Cortex Moutan Radicis with dose proportion of 8:4:4:3:3:3. Although clinical trials have been lacking, various pharmacological actions for Yukmijihwang-tang has been identified newly using animal models. In addition, it was reported that Yukmijihwang-tang increases structural chromosome aberrations significantly in Chinese hamster lung cells. In this article, it is purposed that new studies for pharmacology and toxicology of Yukmijihwang-tang are reviewed. Insight into new studies of Yukmijihwang-tang at the cellular and animal levels will enhance our understanding of Yukmijihwang -tang against various diseases will provide new tools to diagnose and treat patients.
Methods : Recent researches for Yukmijihwang-tang were reviewed and summarized in terms of pharmacological action and toxicity. All sources for review were based on recent studies loaded on data base of web sites such as Science Direct and National Center for Biotechnology Information.
Results and Conclusions : Recently, reports showed that YMJ had antiaging effects, antioxidant and free radical scavenging activities, anti-renal hypertension and prevented tumors, and diabetes mellitus. However, there is little information on its safety except general toxicity, acute and sub-chronic oral toxicity, or genotoxicity. In addition, clinical trial for Yukmijihwang-tang was limited even though Yukmijihwang-tang has been used extensively in Korean traditional medicine. Thus, further studies are necessary to focus on safety evaluation and clinical trial for Yukmijihwang-tang.

참고자료

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