마우스를 이용한 발효쌍화탕의 급성독성 실험 (Acute Toxicity Study on Fermented Ssanghwa-tang Extracts in Mice)

서지정보

· 발행기관 : 대한한방내과학회
· 수록지 정보 : 대한한방내과학회지 / 30권 / 4호 / 780 ~ 787페이지
· 저자명 : 이지혜, 엄영란, 심기석, 전원경, 이재훈, 마진열

초록

Purpose : This study was carried out to investigate the acute toxicity and safety of fermented Ssanghwa-tang extract.
Methods : To evaluate the acute toxity and safety, 0(control group), 1250, 2500 and 5000 ㎎/㎏ of Ssanghwa-tang and fermented Ssanghwa-tang extracts were orally administered to 20 male and 20 female ICR mice. After single administration, we observed survival rates, general toxicity, changes of body weight, and autopsy.
Results : Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 ㎎/㎏).
Conclusions : LD50 of Ssanghwa-tang and fermented Ssanghwa-tang extracts might be over 5000 ㎎/㎏ and it is very safe to ICR mice.

영어초록

Purpose : This study was carried out to investigate the acute toxicity and safety of fermented Ssanghwa-tang extract.
Methods : To evaluate the acute toxity and safety, 0(control group), 1250, 2500 and 5000 ㎎/㎏ of Ssanghwa-tang and fermented Ssanghwa-tang extracts were orally administered to 20 male and 20 female ICR mice. After single administration, we observed survival rates, general toxicity, changes of body weight, and autopsy.
Results : Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 ㎎/㎏).
Conclusions : LD50 of Ssanghwa-tang and fermented Ssanghwa-tang extracts might be over 5000 ㎎/㎏ and it is very safe to ICR mice.

참고자료

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