발효 갈근탕과 쌍화탕의 혈소판 응집 억제 효과 연구 (Anti-platelet Aggregation Study of Fermented Galgeun Tang and Fermented Ssanghwa Tang)

서지정보

· 발행기관 : 대한약학회
· 수록지 정보 : 약 학 회 지 / 55권 / 5호 / 374 ~ 378페이지
· 저자명 : 손추영, 송병정, 마진열, 권광일

초록

This study was performed to evaluate enhanced effect of fermented Galgeun tang (GGT) and Ssanghwa tang (SHT) on the anti-platelet aggregation. Platelet aggregation assay was performed In vitro using human platelet rich plasma(PRP) and In vivo using SD-rat plasma by platelet aggregometer. Pharmacodynamic parameters, E_(max) and EC_50, were calculated using Winnolin. SD-rats administered 1 g/kg of oriental medicine every 12 hr for 8 days. Platelet aggregation was measured by optical method with collagen inducer (4 μg/ml). In In vitro anti-platelet study, EC_50 of GGT-A was lower than that of GGT-con about 79.13 μg/ml. And EC_50 of SHT-A and SHT-B was lower than that of SHT-con about 122.73 and 110.15 μg/ml, respectively. It is assumed that fermented GGT and SHT were more effective than original medicine. In multiple administration study, anti-platelet effect was significantly increased both GGT and SHT. Fermented GGT and SHT were more effective than original herbal medicine on anti-platelet aggregation.

영어초록

This study was performed to evaluate enhanced effect of fermented Galgeun tang (GGT) and Ssanghwa tang (SHT) on the anti-platelet aggregation. Platelet aggregation assay was performed In vitro using human platelet rich plasma(PRP) and In vivo using SD-rat plasma by platelet aggregometer. Pharmacodynamic parameters, E_(max) and EC_50, were calculated using Winnolin. SD-rats administered 1 g/kg of oriental medicine every 12 hr for 8 days. Platelet aggregation was measured by optical method with collagen inducer (4 μg/ml). In In vitro anti-platelet study, EC_50 of GGT-A was lower than that of GGT-con about 79.13 μg/ml. And EC_50 of SHT-A and SHT-B was lower than that of SHT-con about 122.73 and 110.15 μg/ml, respectively. It is assumed that fermented GGT and SHT were more effective than original medicine. In multiple administration study, anti-platelet effect was significantly increased both GGT and SHT. Fermented GGT and SHT were more effective than original herbal medicine on anti-platelet aggregation.

참고자료

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