정상 혈청 총 IgE치를 보이는 알레르기 천식환자의 임상적 특성 (Clinical Characteristics of Allergic Asthmatics with Normal Total Serum IgE Levels)

서지정보

· 발행기관 : 대한천식알레르기학회
· 수록지 정보 : 천식 및 알레르기 / 29권 / 2호 / 96 ~ 104페이지
· 저자명 : 최인선, 김옥기, 정성훈, 이우진, 이성지, 신홍준, 한의령, 정지민

초록

Background: Although allergic diseases occur through IgE-mediated reaction, about 20% of allergic asthmatics have normal total serum IgE levels.
Objective: To characterize the allergic asthmatics with normal total serum IgE levels.
Method: Medical records of 430 consecutive allergic asthmatics, who received the tests for both total IgE and allergen-specific IgE in the serum or on the skin, were reviewed. According to the total and specific IgE levels, the subjects were classified to 4 groups (I, increased/strong; Ⅱ, normal/strong; Ⅲ, increased/weak; Ⅳ, normal/weak).
Result: The Dermatophagoides farinae-specific IgE level in the serum was significantly related to the total serum IgE level (r=0.322, P＜0.001). The D. farinae-specific IgE le-

vels were significantly lower in the group Ⅱ than in the group Ⅰ (3.27±0.14 vs. 1.83±0.30, P＜0.01) and the group Ⅳ than in the group Ⅲ (0.79±0.05 vs. 0.44±0.13, P＜0.01). The results for D. pteronyssinus and sum of checked allergens were similar. The proportion of the patients sensitized to single allergen to total subjects was 7.5%/13.5%/ 33.0%/40.0% for Ⅰ/Ⅱ/Ⅲ/Ⅳ groups (χ2=44.5, P＜0.001).
Conclusion: The allergic asthmatics with normal total serum IgE levels had lower allergen-specific IgE levels and a higher proportion of the patients sensitized to single allergen. The levels of total serum IgE may be determined by the degree of sensitization in allergic asthma.

영어초록

Background: Although allergic diseases occur through IgE-mediated reaction, about 20% of allergic asthmatics have normal total serum IgE levels.
Objective: To characterize the allergic asthmatics with normal total serum IgE levels.
Method: Medical records of 430 consecutive allergic asthmatics, who received the tests for both total IgE and allergen-specific IgE in the serum or on the skin, were reviewed. According to the total and specific IgE levels, the subjects were classified to 4 groups (I, increased/strong; Ⅱ, normal/strong; Ⅲ, increased/weak; Ⅳ, normal/weak).
Result: The Dermatophagoides farinae-specific IgE level in the serum was significantly related to the total serum IgE level (r=0.322, P＜0.001). The D. farinae-specific IgE le-

vels were significantly lower in the group Ⅱ than in the group Ⅰ (3.27±0.14 vs. 1.83±0.30, P＜0.01) and the group Ⅳ than in the group Ⅲ (0.79±0.05 vs. 0.44±0.13, P＜0.01). The results for D. pteronyssinus and sum of checked allergens were similar. The proportion of the patients sensitized to single allergen to total subjects was 7.5%/13.5%/ 33.0%/40.0% for Ⅰ/Ⅱ/Ⅲ/Ⅳ groups (χ2=44.5, P＜0.001).
Conclusion: The allergic asthmatics with normal total serum IgE levels had lower allergen-specific IgE levels and a higher proportion of the patients sensitized to single allergen. The levels of total serum IgE may be determined by the degree of sensitization in allergic asthma.

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