Dexmedetomidine의 정주가 상완 신경총 차단의 작용시간에 미치는 효과 (The effect of intravenous dexmedetomidine on the duration of brachial plexus block)

서지정보

· 발행기관 : 대한마취통증의학회
· 수록지 정보 : Anesthesia and Pain Medicine / 7권 / 4호 / 307 ~ 311페이지
· 저자명 : 박지웅, 한정욱, 신혜란, 정종권, 차영덕, 강성안, 송장호

초록

Background: Dexmedemomidine, a highly selective alpha-2adrenoreceptor agonist has an analgesic and sedative effect without causing respiratory depression. In this study, we compared the duration of brachial plexus block (BPB), the time at which the patient first feels pain after performing BPB, the need for use of analgesics, and the occurrence rate of complications while continuous infusion with dexmedetomidine was used for sedation in patients undergoing BPB, to a control group, who were only infused with normal saline.
Methods: BPB was performed in 48 patients scheduled for upper limb surgery. Infraclavicular approach was provided with 40 ml of 1.5% mepivacaine and 200 μg of epinephrine using nerve stimulator.
After verification of successful block, dexmedetomidine group received dexmedetomidine (loading dose 0.1 μg/kg/min for the first 10 minutes followed by a maintenance dose of 0.005 μg/kg/min as required to maintain bispectral index 60−80). In the control group, normal saline was infused at a rate of 10 ml/hr. The duration of BPB, the time at which the patient first feels pain after performing BPB, frequency of complication, and the use of analgesics of the both groups were checked.
Results: The motor and sensory block duration, and the time at which the patient first feels pain after BPB were longer in the dexmedetomidine group compared to the control group. And the need for analgesics were less in the dexmedetomidine group.
Conclusions: Intravenous administration of dexmedetomidine prolongs the duration of BPB.

영어초록

Background: Dexmedemomidine, a highly selective alpha-2adrenoreceptor agonist has an analgesic and sedative effect without causing respiratory depression. In this study, we compared the duration of brachial plexus block (BPB), the time at which the patient first feels pain after performing BPB, the need for use of analgesics, and the occurrence rate of complications while continuous infusion with dexmedetomidine was used for sedation in patients undergoing BPB, to a control group, who were only infused with normal saline.
Methods: BPB was performed in 48 patients scheduled for upper limb surgery. Infraclavicular approach was provided with 40 ml of 1.5% mepivacaine and 200 μg of epinephrine using nerve stimulator.
After verification of successful block, dexmedetomidine group received dexmedetomidine (loading dose 0.1 μg/kg/min for the first 10 minutes followed by a maintenance dose of 0.005 μg/kg/min as required to maintain bispectral index 60−80). In the control group, normal saline was infused at a rate of 10 ml/hr. The duration of BPB, the time at which the patient first feels pain after performing BPB, frequency of complication, and the use of analgesics of the both groups were checked.
Results: The motor and sensory block duration, and the time at which the patient first feels pain after BPB were longer in the dexmedetomidine group compared to the control group. And the need for analgesics were less in the dexmedetomidine group.
Conclusions: Intravenous administration of dexmedetomidine prolongs the duration of BPB.

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