백화사설초(Hedyotis diffusa Willd) 에탄올 추출물의 Hyaluronic Acid 합성 효과 (The Effect of Hedyotis diffusa Willd Ethanol Extract on Hyaluronic Acid Synthesis)

서지정보

· 발행기관 : 대한미용학회
· 수록지 정보 : 대한미용학회지 / 19권 / 3호 / 135 ~ 140페이지
· 저자명 : 하헌용

초록

Hedyotis diffusa Willd, a plant belonging to the Rubiaceae, is mainly used for medicinal purposes. It has traditionally been used in treatment of carcinoma and to neutralize snake venom. Currently, it is also widely used as a raw material for pharmaceuticals and cosmetics. Hyaluronic acid is an essential molecule for maintaining a moisturizing effect in human cells, including keratinocytes. We conducted an experiment to determine the effect of hyaluronic acid biosynthesis of Hedyotis diffusa Willd. on human skin. The results of the experiment confirmed that Hedyotis diffusa Willd. did not exhibit cytotoxicity in animal cells. The results showed that the expression of genes related to hyaluronic acid synthesis and the amount of hyaluronic acid produced on keratinocytes also increased. In particular, the biosynthetic effect of hyaluronic acid reached 106% compared to the positive control all trans retinoic acid (ATRA).
Based on these results, it was determined that apples could exhibit a skin moisturizing effect by promoting production of hyaluronic acid in animal cells

영어초록

Hedyotis diffusa Willd, a plant belonging to the Rubiaceae, is mainly used for medicinal purposes. It has traditionally been used in treatment of carcinoma and to neutralize snake venom. Currently, it is also widely used as a raw material for pharmaceuticals and cosmetics. Hyaluronic acid is an essential molecule for maintaining a moisturizing effect in human cells, including keratinocytes. We conducted an experiment to determine the effect of hyaluronic acid biosynthesis of Hedyotis diffusa Willd. on human skin. The results of the experiment confirmed that Hedyotis diffusa Willd. did not exhibit cytotoxicity in animal cells. The results showed that the expression of genes related to hyaluronic acid synthesis and the amount of hyaluronic acid produced on keratinocytes also increased. In particular, the biosynthetic effect of hyaluronic acid reached 106% compared to the positive control all trans retinoic acid (ATRA).
Based on these results, it was determined that apples could exhibit a skin moisturizing effect by promoting production of hyaluronic acid in animal cells

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