淸華湯의 항산화 및 항염증 효능 (Effect of CHT in anti-oxidative and anti-inflammatory related factors)

서지정보

· 발행기관 : 대전대학교 한의학연구소
· 수록지 정보 : 한의학연구소 논문집 / 20권 / 2호 / 29 ~ 40페이지
· 저자명 : 김진우, Gim Seon-Bin, Oh Jeong- Min, Yun Mi-Young, Lee Ki-Moo, 김동희

초록

To investigate the clinical aspects of CHT in atopic dermatitis (AD) treatments, the effect of CHT in anti-oxidative and anti-inflammatory cytokines were tested. 100% or higher cell viability was observed in all tested groups from 25 to 200 ㎍/㎖ using Raw 264.7 cells. CHT showed dose-dependent DPPH scavenging activity, with more than 90% scavenging activities at 800 ㎍/㎖ concentrations. CHT showed dose-dependent suppression activity of ROS production, especially at 200 ㎍/㎖ of 37.5%. CHT decreased NO production activity, with significant decrease of 33.2% at 200 ㎍/㎖. IL-6, MCP-1, TNF-α production rate were decreased by approximately 25% when Raw 264.7 cells were treated with LPS and with CHT of 200 ㎍/㎖. Also, IL-1βproduction rate was decreased by 25% at 100 ㎍/㎖. The results above indicate that CHT significantly reduces the effect of oxidative and inflammatory cytokines. The use of CHT in dermatitis can be widely suggested.

영어초록

To investigate the clinical aspects of CHT in atopic dermatitis (AD) treatments, the effect of CHT in anti-oxidative and anti-inflammatory cytokines were tested. 100% or higher cell viability was observed in all tested groups from 25 to 200 ㎍/㎖ using Raw 264.7 cells. CHT showed dose-dependent DPPH scavenging activity, with more than 90% scavenging activities at 800 ㎍/㎖ concentrations. CHT showed dose-dependent suppression activity of ROS production, especially at 200 ㎍/㎖ of 37.5%. CHT decreased NO production activity, with significant decrease of 33.2% at 200 ㎍/㎖. IL-6, MCP-1, TNF-α production rate were decreased by approximately 25% when Raw 264.7 cells were treated with LPS and with CHT of 200 ㎍/㎖. Also, IL-1βproduction rate was decreased by 25% at 100 ㎍/㎖. The results above indicate that CHT significantly reduces the effect of oxidative and inflammatory cytokines. The use of CHT in dermatitis can be widely suggested.

참고자료

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