두부 손상이 없는 골절 환자에서 혈중 S100B 단백질의 분석 (S-100B in Extracranial Fracture Patients Without Head Trauma)

서지정보

· 발행기관 : 대한외상학회
· 수록지 정보 : 대한외상학회지 / 22권 / 2호 / 123 ~ 127페이지
· 저자명 : 박태웅, 이동훈, 이상진, 김성은, 김찬웅

초록

Purpose: There is an increasing amount of evidence that S100B could function as a marker of brain damage.
However, the cerebral specificity of S100B has been questioned, so the extracerebral sources of S100B have
been paid attention. We performed this investigation to show serum S100B levels after extracranial fracture in
patients without current head injury and without prior neurological disease.
Methods: At the emergency department, we obtained the blood samples within 6 hours from trauma patients
hospitalized with extracranial fractures. S100B levels were compared between one fracture and more than two
fractures, and analyzed according to the presence of soft tissue damage.
Results: Patients with one fracture and those with more than two fractures did not differ by age (mean, 54.70
vs. 47.03, p=0.130), and there was no significant difference in the male-to-female ratio(33:32 vs. 21:12,
p=0.226). In patients with one fracture, the mean value of S-100B was 0.56 μg/L (95% CI: 0.35-0.77) whereas
in those with more than two fractures, the corresponding value was 1.09 μg/L (95% CI: 0.46-1.7, p=0.048). The
S100B level of patients with soft tissue damage(1.32±0.38) was higher than that of patients without soft tissue
damage(0.81±0.21), whether one fracture or more than two fractures(p=0.049).
Conclusion: We present here that S100B levels were raised in 77% of patients with extracranial fractures
without cerebral injury who were hospitalized from the emergency room and that the presence of soft tissue
damage contributed to the increased S100B rather than the size of the fractured bone size or the number of fracturest.
Thus, this study suggests that soft tissue injury may be considered as an important extracerebral source
of S100B.

영어초록

Purpose: There is an increasing amount of evidence that S100B could function as a marker of brain damage.
However, the cerebral specificity of S100B has been questioned, so the extracerebral sources of S100B have
been paid attention. We performed this investigation to show serum S100B levels after extracranial fracture in
patients without current head injury and without prior neurological disease.
Methods: At the emergency department, we obtained the blood samples within 6 hours from trauma patients
hospitalized with extracranial fractures. S100B levels were compared between one fracture and more than two
fractures, and analyzed according to the presence of soft tissue damage.
Results: Patients with one fracture and those with more than two fractures did not differ by age (mean, 54.70
vs. 47.03, p=0.130), and there was no significant difference in the male-to-female ratio(33:32 vs. 21:12,
p=0.226). In patients with one fracture, the mean value of S-100B was 0.56 μg/L (95% CI: 0.35-0.77) whereas
in those with more than two fractures, the corresponding value was 1.09 μg/L (95% CI: 0.46-1.7, p=0.048). The
S100B level of patients with soft tissue damage(1.32±0.38) was higher than that of patients without soft tissue
damage(0.81±0.21), whether one fracture or more than two fractures(p=0.049).
Conclusion: We present here that S100B levels were raised in 77% of patients with extracranial fractures
without cerebral injury who were hospitalized from the emergency room and that the presence of soft tissue
damage contributed to the increased S100B rather than the size of the fractured bone size or the number of fracturest.
Thus, this study suggests that soft tissue injury may be considered as an important extracerebral source
of S100B.

참고자료

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