저칼륨혈증을 동반한 고혈압으로 발현한 원발성 레닌증 1예 (A Case of Primary Reninism Manifested by Hypertension with Hypokalemia)

서지정보

· 발행기관 : 대한내분비학회
· 수록지 정보 : Endocrinology and Metabolism / 20권 / 2호 / 168 ~ 173페이지
· 저자명 : 최형진, 홍의실, 조영민, 박도준, 신찬수, 박경수, 김성연, 조보연, 이홍규

초록

원발성 레닌증(primary reninism)은 드문 질환으로 고혈압과 저칼륨혈증을 발생시키는 질환이다. 높은 혈중 레닌 활성도와 고알도스테론증이 관찰되는 질환으로, 신혈관성 고혈압, 원발성 알도스테론증과 같은 고알도스테론증의 다른 원인 질환들과의 감별이 중요하다. 원발성 레닌증의 가장 흔한 임상질환인 juxtaglomerular cell tumor는 고혈압의 원인 중 완치가 가능한 원인 질환이며, 보존적인 수술만으로도 성공적으로 완치 될 수 있다. 저자들은 우연히 발견된 고혈압을 주소로 내원하여 juxtaglomerular cell tumor로 진단 받고 수술적 치료로 완치된 22세 여자 환자 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

영어초록

Primary reninism is a rare cause of hypertension manifesting along with hypokalemia. A high level of plasma renin activity and a high level of serum aldosterone are the whole markers of primary reninism. Upon making the diagnosis of primary reninism, other more common causes of aldosteronism must be differentiated, such as renovascular hypertension and primary aldosteronism. Primary reninism is commonly caused by juxtaglomerular cell tumor, which is one of the curable causes of hypertension, and this can be successfully treated by conservative surgery. We report here on a case of primary reninism that was caused by juxtaglomerular cell tumor that developed in a 22-year-old female patient. She was recently diagnosed with hypertension and hypokalemia. She had markedly elevated plasma renin activity and an increased serum aldosterone concentration. Computed tomography revealed a mass located in the right kidney and selective renal vein sampling suggested that the mass was secreting an excess of renin. Right nephrectomy was done and her hypertension with hypokalemia was successfully treated. We report here a case of primary reninism that presented with juxtaglomerular cell tumor along with a review of the literature

참고자료

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