자살을 시도한 우울증 환자에서 혈장 ß -Nerve Growth Factor 농도의 변화 (Alteration of plasma ？-Nerve Growth Factor concentration in depressed patients with suicidal attempt)

서지정보

· 발행기관 : 대한생물정신의학회
· 수록지 정보 : 생물정신의학 / 13권 / 2호 / 18 ~ 25페이지
· 저자명 : 심세훈, 김용구, 권영준, 이분희, 원성두, 양종철

초록

ObjectNerve growth factor(NGF) is a protein involved in neuronal survival and plasticity in the central nervous system, which might play an important role in stress, depression and suicide. This study was performed to determine whether there is an alteration in plasma NGF concentrations in depressed patients with suicidal attempt.MethodsThe subjects were 32 depressed patients who attempted suicide and admitted in emergency room. Forty-four hospitalized non-suicidal depressive patients and the 30 normal controls were closely matched with the suicidal group in terms of age and sex. Individuals in all 3 groups were evaluated independently by a semi-structured interview for the purpose of establishing a DSM-IV criteria diagnosis. The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). The severity of the suicidal behavior was evaluated by Weisman and Wordens risk-rescue rating (RRR) system and the Lethality Suicide Attempt Rating Scale (LSARS). Plasma NGF level was measured by the enzyme linked immunosorbent assay (ELISA) method.

영어초록

ObjectNerve growth factor(NGF) is a protein involved in neuronal survival and plasticity in the central nervous system, which might play an important role in stress, depression and suicide. This study was performed to determine whether there is an alteration in plasma NGF concentrations in depressed patients with suicidal attempt.MethodsThe subjects were 32 depressed patients who attempted suicide and admitted in emergency room. Forty-four hospitalized non-suicidal depressive patients and the 30 normal controls were closely matched with the suicidal group in terms of age and sex. Individuals in all 3 groups were evaluated independently by a semi-structured interview for the purpose of establishing a DSM-IV criteria diagnosis. The severity of depressive symptoms was evaluated using Hamilton depression rating scale (HDRS). The severity of the suicidal behavior was evaluated by Weisman and Wordens risk-rescue rating (RRR) system and the Lethality Suicide Attempt Rating Scale (LSARS). Plasma NGF level was measured by the enzyme linked immunosorbent assay (ELISA) method.

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